Original Article
Influence of dezocine combined with dexamethasone intravenous analgesia on serum inflammatory factors and cellular immunity in the patient after radical mastectomy
Wumin Bai, Wei Luo, Shuangyin Zhang, Min Wang, Huinian Zhou, Yingbin Wang
Published 2018-06-25
Cite as Pain Clin J, 2018, 14(3): 180-185. DOI: 10.3760/cma.j.issn.1672-9633.2018.03.005
Abstract
ObjectiveTo investigate the influence of dezocine combined with dexamethasone intravenous analgesia on serum inflammatory factors and cellular immunity in the patient after radical mastectomy.
MethodsEighty patients with radical mastectomy were randomly divided into combined group and dezocine group from April 2016 to April 2017 in Lanzhou University Second Hospital, forty cases in each group. The patients in dezocine group were given dezocine intravenous drip at 30 min before the end of operation, and dexamethasone combined with dezocine intravenous drip in combined group. Visual analogue scale (VAS), serum inflammatory factor including interleukin-2 (IL-2), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α), the immune cells including CD3+, CD4+, CD8+, CD4+/CD8+ and natural killer cells (NK), and the occurrence of adverse reactions were recorded and compared.
ResultsVAS was lower in combined group than that in dezocine group at 12, 24 h after the operation (P<0.05). The expression of IL-2 was lower at 1, 3 d postoperatively as compared with preoperation, and even lower in combined group (P<0.05).The expression of IL-6 and TNF-α was higher at 1, 3 d postoperatively as compared with preoperation in the two groups, and even higher in dezocine group (P<0.05). The expression of CD3+, CD4+, CD4+/CD8+and NK was lower at 1, 3 d postoperatively as compared with preoperation in the two groups, and even lower in dezocine group (P<0.05), while the expression of CD8+was higher, and even higher in dezocine group (P<0.05). The total incidence of adverse reactions such as respiratory depression, nausea, vomiting and hypotension was 20% (8/40 cases) in combined group, which was significantly lower than 45% (18/40 cases) in dezocine group (P<0.05).
ConclusionDezocine combined with dexamethasone intravenous analgesia can effectively reduce the inflammatory reaction, improve the cellular immune function, and decrease the incidence of adverse reactions in the patient after radical mastectomy.
Key words:
Dezocine; Dexamethasone; Breast neoplasms; Inflammatory factor; Cellular immunity
Contributor Information
Wumin Bai
Department of Anesthesiology, Lanzhou University Second Hospital, Gansu Province 730030, China
Wei Luo
Shuangyin Zhang
Min Wang
Huinian Zhou
Yingbin Wang
