To observe the efficacy of dezocine combined with propofol for analgesia during radiofrequency thermocoagulation on trigeminal ganglion in the treatment of patients with primary trigeminal neuralgia.

Sixty patients with trigeminal neuralgia in Zhongshan People's Hospital of Guangdong Province from October 2015 to October 2017, undergoing radiofrequency thermocoagulation on trigeminal ganglion, were randomly divided into compound group (30 cases) and propofol group (30 cases). Patients received anesthesia with dezocine combined with propofol in the compound group, intravenous dezocine 5 mg at first, then propofol 2.5-3.5 mg/kg was followed by continuous infusion at the rate of 1.0-2.5 mg·kg^-1·h^-1 after 1 min, While patients received propofol only in the propofol group. MAP, HR and SpO₂, propofol dosage, analgesia time, the incidences of intraoperative respiratory depression and bradycardia were recorded in the two groups.

MAP was lower significantly in the propofol group than that in the compound group during anesthesia induction and operative thermocoagulation (P<0.05). The dosage of propofol was higher significantly in the propofol group than that in the compound group (P<0.05). The incidences of body movement, respiratory depression and bradycardia were less significantly in the compound group than those in the propofol group (P<0.05).

Dezocine combined with propofol is superior to propofol only for analgesia during radiofrequency thermocoagulation on trigeminal ganglion in the treatment of patients with primary trigeminal neuralgia, with less adverse reactions.

Analgesics, opioid; Disoprofol; Trigeminal neuralgia; Radiofrequency thermocoagulation