To investigate the impact of vasectomy on the aging males’ symptoms (AMS) score.

Participants aged ≥40 years were randomly sampled by stratified-cluster method. A questionnaire and a physical examination were taken for each one, and combining both results to analyze the impact of vasectomy on AMS score.

The positive rate of AMS symptom and the AMS score in the ligation group (38.7±10.8) was higher than the non-ligation group (31.3±10.0) (P<0.05). After adjusted by possible confounding factors, the statistically significant (P<0.05) difference was found in somatic symptoms (b=2.235, 95% CI=1.29-3.36), psychological symptoms (b=0.805, 95% CI=0.09-1.52), sexual functional symptoms (b=2.693, 95% CI=1.97-3.42) and total score of AMS (b=5.809, 95% CI=3.86-7.76), all grouped by ligation. The score of sexual function in the 10-year ligation group was higher than control group with the same age (P<0.05). The scores of somatic symptoms, sexual symptom and AMS were higher than control group with the same age (P<0.05). The scores of somatic symptoms (15.2±5.5, 16.8±6.3), sexual symptom (13.8±3.9, 14.6±3.5) and AMS (37.6±9.9, 40.3±11.0) in the 20-year and 30-year ligation group were higher than control group (13.2±4.8, 13.5±4.8), (10.8±4.1, 11.1±4.2), (31.7±9.9, 32.3±10.0) with the same age (P<0.05). The scores of psychological symptoms (8.9±4.1) was higher in the 30-year group than control group (7.7±3.3) with the same age (P<0.05). The scores of somatic symptoms, psychological symptoms, sexual function and AMS were higher in the 30-year group than control group with the same age (P<0.05).

The vasectomy may increase AMS score, especially distinct in the participants with long-term vasectomy.

Vasectomy; Aging males’ symptoms scale (AMS); Late-onset hypogonadism (LOH)