Review
Research progress of the relationship between perfluoroalkyl and polyfluoroalkyl substances and human reproduction
Zhou Yuanyuan, Shen Juan, Mao Yuchan, Jin Fan
Published 2018-11-25
Cite as Chin J Reprod Contracep, 2018,38(11): 940-945. DOI: 10.3760/cma.j.issn.2096-2916.2018.11.013
Abstract
Perfluoroalkyl and polyfluoroalkyl substances (PFASs) are a group of environmental endocrine disruptors (EEDs) that are widespread in the environment and organisms, including perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA). A large number of experimental and epidemiological investigations have shown that PFASs exposure is associated with disorders of human reproduction. The present review focuses on the effect of PFASs on the human reproduction, including their associations with the development of germ cells, the secretion of reproductive hormone, the health of the offspring and so on. The problems and prospect in the research of PFASs have been discussed.
Key words:
Perfluoroalkyl and polyfluoroalkyl substances (PFASs); Environmental endocrine disruptors (EEDs); Human reproduction
Contributor Information
Zhou Yuanyuan
Medical Center for Human Reproduction, Women’s Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China
Shen Juan
Medical Center for Human Reproduction, Women’s Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China
Mao Yuchan
Medical Center for Human Reproduction, Women’s Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China
Jin Fan
Medical Center for Human Reproduction, Women’s Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China
