Objective To study the value of ~1H-MRSI in the diagnosis of cerebral glioblastoma.Methods 29 patients with cerebral glioblastoma confirmed by postoperative pathology were examined with routine MRI and ~1H-MILSI before operation.The preoperative pathological diagnosis was presumed according to the MRI and ~1H-MRSI for each patient.The characteristics of ~1H-MRSI in glioblastoma were concluded.Results The preoperative right presumption of diagnosis was achieved in 25 patients.The typical ~1H-MRSI features of cerebral glioblastoma included:evident decrease of NAA,increase of Cho,significant increase of the Cr/NAA ratio within or at the edge of tumors.and the appearance of Lac.Conclusion Significant ilrlcreage of the Cr/NAA ratio within or at the edge of tumors is the main characteristic of ~1H-MRSI in cerebral glioblastom Preoperative ~1H-MRSI is of certain value in the diagnosis of cerebral glioblastoma.