Objective To study the relationship between the preoperative resting-state functional magnetic resonance imaging ( fMRI ) based on blood oxygen level dependent (BOLD) technique and electric cortical stimulationfor cortical mapping of primary motor cortex in patients with tumors near the central area.To research whether non-invasive preoperative resting-state fMRI can provide information equivalent to those achieved with the invasive neurosurgical " gold standard".Methods A prospective study of 18 patients with various pathological tumors of the central area was conducted.Preoperative resting-state fMRI Resting functional connectivity fMRI was documented in sequence,and compared to standardized direct electric cortical stimulation.The compound muscle action potentials of forearm flexor and hand muscle responses were recorded during DCES.Results The intraoperative direct electric cortical stimulationshowed good correlation with resting-state fMRI activation in 92.9％ of cases.Conclusions Resting-state fMRI is a high sensitive and reliable technique to locate the position of the motor areas and their spatial relation with adjacent tumor,especially for the presurgical planning in patients with central area brain tumor.