Objective To study the relationship with inflammatory levels and indicators and the clinical outcomes in craniopharyngioma.Methods Evaluating the inflammatory levels of craniopharyngioma on the basis of the number of inflammatory cells at the interface of tumor and normal tissues.The relationship between grades of inflammation and clinicopathological indicators and clinical outcomes were analyzed in 49 cases of craniopharyngomas.Results The inflammation of craniopharyngioma was associated with the pathological classification (x2 =6.603,P=0.037),the rate of total resection (x2 =8.188,P=0.017),calcification (γ=0.326,P=0.022),postoperative hypothalamic status scale (γ=0.376,P=0.008),and surgical difficulty (γ =0.515,P＜0.001).Conclusions The origin,growth patterns,and inflammatory levels of craniopharyngioma could be important factors that determine the prognosis of craniopharyngiomas.