Objective To explore the surgical skills,effects and complications of Tailored Temporal lobectomy via the anterolateral Approach for the treatment of mesial temporal lobe epilepsy (MTLE).Methods The Temporal lobectomy via the anterolateral Approach was performed under the guidance of functional brain mapping and neuronavigation system in 21 patients with intractable MTLE.All the patients were followed up from 6 to 29 months after surgeries.Results In 21 patients,16 patients (76％),3 patients(14％) and 2 patients(10％) belonged in Engel grade Ⅰ (seizure-free),grade Ⅱ (rare seizures) and grade Ⅲ (worthwhile improvement),respectively.Neuro-functions were improved after the surgeries in 16 patients.No severe complications occurred in all the patients.Conclusions The Temporal lobectomy via the anterolateral Approach under the guidance of functional brain mapping and neuronavigation system is an effective method of treating intractable MTLE because the volume of medial hippocampus and amygdala removal is extremely variable.It also provides a protective way of the optic radiation and language area.