Brain Neoplasms
Diagnosis and treatment of supratentorial tumors with small round cell malignancies diagnosed by intraoperative rapid pathology
Li Zhiyong, Yi Guozhong, Huang Guanglong, Zhang Xi′an, Song Ye, Wang Hai, Fang Luxiong, Liu Yawei, Pan Jun, Qi Songtao
Published 2020-01-28
Cite as Chin J Neurosurg, 2020,36(01): 21-25. DOI: 10.3760/cma.j.issn.1001-2346.2020.01.006
Abstract
ObjectiveTo explore the diagnosis and treatment of supratentorial tumors with small round cell malignancies diagnosed by intraoperative rapid pathology.
MethodsA retrospective analysis was conducted on the clinical data of 36 patients with supratentorial tumors diagnosed as small round cell malignant tumors by intraoperative frozen pathology at Department of Neurosurgery, Nanfang Hospital, Southern Medical University from January 2011 to December 2017. All patients were treated with complete tumor resection according to the principle of glioma operation. After the operation, the MRI of the head was reexamined, and the volume quantitative analysis was used to determine the degree of tumor resection, which was divided into complete resection, subtotal resection and partial resection. All patients were followed up regularly in outpatient department, and MRI was reexamined to explore the recurrence of tumor.
ResultsMRI of 36 patients after operation showed that 31 patients (86.1%) had complete resection and 5 patients (13.9%) had subtotal resection. The results of pathological diagnosis were as follows: primary central nervous system lymphoma (10 cases), glioblastoma (6 cases), central neurocytoma (5 cases), primitive neuroectodermal tumors (3 cases), brain metastasis tumor (2 cases), pineal cell tumors(2 cases), ependymoblastoma (2 cases), World Health Organization (WHO) grade Ⅱ glioma (2 cases), pituitary adenoma (1 case), periangioblastoma (1 case), olfactory neuroblastoma(1 case) and desmoplastic small round cell tumor (1 case). Among the 33 patients diagnosed by MRI before operation, 8 (24.2%) had the same pathological results with preoperative diagnosis, including 4 cases of lymphoma, 1 case of central neurocytoma, 1 case of primitive neuroectodermal tumor, 1 case of hemangioblastoma and 1 case of metastasis. The follow-up duration of 36 patients was 28.9±8.1 months and ranged from 6 to 70 months . During the follow-up period, 26 out of 36 patients (72.2%) relapsed.
ConclusionsThe supratentorial tumors with small round cell malignant tumor diagnosed by rapid pathology during operation should be resected in the maximal range under the premise of safety, the pathological results are various and its therapeutic effect seems relatively good.
Key words:
Supratentorial tumor; Pathology; Treatment outcome; In operation; Small round cell tumor
Contributor Information
Li Zhiyong
Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
Yi Guozhong
Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
Huang Guanglong
Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
Zhang Xi′an
Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
Song Ye
Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
Wang Hai
Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
Fang Luxiong
Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
Liu Yawei
Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
Pan Jun
Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
Qi Songtao
Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
