Original Article
The impact of red blood cell distribution width on outcome of elective percutaneous coronary intervention in non-anemia patients
Xinmin Liu, Jianzeng Dong, Xiaohui Liu, Junping Kang, Taiyang Luo, Yang Guan, Tianyi Dai, Yin Zhang, Rong Bai, Xin Du, Changsheng Ma
Published 2016-12-01
Cite as Chin J Intern Med, 2016, 55(12): 937-940. DOI: 10.3760/cma.j.issn.0578-1426.2016.12.006
Abstract
ObjectivePrevious studies have revealed that the red blood cell distribution width (RDW) was associated with long-term prognosis in patients undergoing percutaneous coronary intervention (PCI). However, they did not exclude patients with anemia. This study, thus, investigated the association between RDW and prognosis in non-anemia patients.
MethodsA total of 2 732 patients underwent elective PCI from July 2009 to September 2011 were enrolled in the study. These patients were divided into two groups based on their baseline median RDW levels: low RDW group (RDW<12.1%) and high RDW group (RDW≥12.1%). All the subjects were followed up for an average period of 18 months and the associations between baseline RDW levels and postoperative mortality were analyzed.
ResultsPatients in the high RDW group were elder and had more women than those in low RDW group. Most of them had prior history of hypertension, stroke, myocardial infarction, but few of them were current smokers. Subjects in the high RDW group had higher systolic blood pressure and total cholesterol levels, and lower erythrocyte mean corpuscular volume, hemoglobin level, estimated glomerular filtration rate level, and left ventricular ejection fraction. Moreover, more subjects in the high RDW group were combined with left main, ostial and chronic total occlusion lesion, and had a lower complete revascularization rate. The postoperative mortality was significantly higher in the high RDW group than that in the low RDW group (2.4% vs 0.6%, P<0.001). Multivariate Cox regression analysis revealed that preoperative high RDW level was an independent risk factor for postoperative mortality after adjustment of other factors (HR 3.930, 95%CI 1.600-9.656, P=0.003).
ConclusionHigh RDW might be a marker for the postoperative mortality in non-anemic patients undergoing elective PCI.
Key words:
Red blood cell distribution width; Angioplasty; Prognosis
Contributor Information
Xinmin Liu
Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China
Jianzeng Dong
Xiaohui Liu
Junping Kang
Taiyang Luo
Yang Guan
Tianyi Dai
Yin Zhang
Rong Bai
Xin Du
Changsheng Ma