Original Article
Ikaros family zinc finger 1 mutation is a poor prognostic factor for adult Philadelphia chromosome positive acute lymphoblastic leukemia
Shanhao Tang, Ying Lu, Pisheng Zhang, Xuhui Liu, Xiaohong Du, Dong Chen, Shuangyue Li, Junjie Cao, Lieguang Chen, Jing Le, Suying Qian, Yongwei Hong, Renzhi Pei
Published 2019-04-01
Cite as Chin J Intern Med, 2019, 58(4): 301-306. DOI: 10.3760/cma.j.issn.0578-1426.2019.04.012
Abstract
ObjectiveTo analyze the prognostic impact of Ikaros family zinc finger 1(IKZF1) mutation on adult Philadelphia chromosome (Ph1) positive acute lymphoblastic leukemia (ALL) patients.
MethodsIKZF1 mutation was detected in 63 adult Ph1 positive ALL patients at diagnosis using capillary electrophoresis. Recruited patients were treated in our center and other three hospitals in Ningbo from January 2014 to January 2017. Clinical data were collected and retrospectively analyzed.
ResultsThirty-nine (61.9%) patients were positive IKZF1 mutation in this cohort. The white blood cell (WBC) count in IKZF1 mutation group was significantly higher than that of mutation negative group [(64.6±11.3)×109/L vs. (33.7±5.6)×109/L, P<0.05]. Patients with WBC count over 30×109/L accounted for 56.4% in IKZF1 mutation group. Complete remission (CR) rate in the IKZF1 mutation group was also lower than that of negative group after induction chemotherapy (64.1% vs. 75.0%, P>0.05). IKZF1 was a negative prognostic factor but not independent factor for survival by univariate and multivariate analyses. Patients were divided into chemotherapy and allogeneic transplantation groups. The 3-year overall survival (OS) rate and 3-year leukemia-free survival (LFS) rate in IKZF1 mutation group were significantly lower than those of negative group in both transplantation group (42.3% vs. 59.3%; 31.2% vs. 50.0%; respectively, both P<0.05) and chemotherapy group (24.8% vs. 40.0%; 19.0% vs. 34.3%; respectively, both P<0.05).
ConclusionIKZF1 mutation is a poor prognostic factor for adult Ph1 positive ALL patients.
Key words:
Philadelphia chromosome; Acute lymphoblastic leukemia; Prognosis; Ikaros family zinc finger 1 gene
Contributor Information
Shanhao Tang
Department of Hematology, Ningbo Yinzhou People′s Hospital, Ningbo 315040, China
Ying Lu
Department of Hematology, Ningbo Yinzhou People′s Hospital, Ningbo 315040, China
Pisheng Zhang
Department of Hematology, Ningbo Yinzhou People′s Hospital, Ningbo 315040, China
Xuhui Liu
Department of Hematology, Ningbo Yinzhou People′s Hospital, Ningbo 315040, China
Xiaohong Du
Department of Hematology, Ningbo Yinzhou People′s Hospital, Ningbo 315040, China
Dong Chen
Department of Hematology, Ningbo Yinzhou People′s Hospital, Ningbo 315040, China
Shuangyue Li
Department of Hematology, Ningbo Yinzhou People′s Hospital, Ningbo 315040, China
Junjie Cao
Department of Hematology, Ningbo Yinzhou People′s Hospital, Ningbo 315040, China
Lieguang Chen
Department of Hematology, Ningbo Yinzhou People′s Hospital, Ningbo 315040, China
Jing Le
Department of Hematology, Ningbo Medical Center Lihuili Eastern Hospital, Ningbo 315040, China
Suying Qian
Department of Hematology, Ningbo No.2 Hospital, Ningbo 315010, China
Yongwei Hong
Department of Hematology, Ningbo Yinzhou No.2 Hospital, Ningbo 315192, China
Renzhi Pei
Department of Hematology, Ningbo Yinzhou People′s Hospital, Ningbo 315040, China
