Original Article
A retrospective analysis of clinical characteristics and mortality risks in elderly patients with acute cholecystitis and cholangitis
Hui Shi, Jun Wan, Shiping Xu, Liang Liao
Published 2019-06-01
Cite as Chin J Intern Med, 2019, 58(6): 415-418. DOI: 10.3760/cma.j.issn.0578-1426.2019.06.003
Abstract
ObjectiveTo analyze the clinical characteristics and explore the risk predictors on mortality in elderly patients with acute cholecystitis and cholangitis.
MethodsWe conducted a retrospective analysis of elderly patients hospitalized in the Second Medical Center of General Liberation Army Hospital for acute cholecystitis and cholangitis during 2000 to 2018. Clinical data and risk predictors on mortality were assessed. The patients were stratified into three groups based on age:Ⅰ (65-74 years old),Ⅱ (75-84 years old), and Ⅲ (≥85 years old). Logistic regression analysis was used to identify the predictors of mortality.
ResultsA total of 574 patients were finally enrolled with the mean age 87.6 years including 191 in group Ⅰ, 167 in group Ⅱ, and 216 in group Ⅲ. The main cause of acute cholecystitis and cholangitis was gallstone (76.3%),and the main symptom was abdominal pain (62.9%),followed by chills(62.5%),fever(59.8%),jaundice (47.2%) and septic shock(26.3%). Cholecystitis was the most common diagnosis in groups Ⅰ and Ⅱ,whereas it was cholangitis in group Ⅲ. Percutaneous transhepatic biliary/gallbladder drainage (PTBD/PTGD) and endoscopic retrograde cholangiopancreatography (ERCP) were administrated more frequently in groups Ⅲ. A total of 35 patients (6.1%) died during follow-up. Senior in age (OR=11.1),the Charlson comorbidity index (OR=19.5),cancers (OR=9.6),blood stream infections (OR=7.4),severity of cholecystitis and cholangitis (OR=4.2) were risk factors associated with mortality.
ConclusionsEven in the elderly patients with acute cholecystitis and cholangitis,comorbidity is one of the main factors affecting clinical outcomes. Due to the poor performance, this group of population presents more severe disease and undergoes conservative treatment strategies.
Key words:
Acute cholecystitis; Acute cholangitis; Clinical characteristics; Mortality; Elderly
Contributor Information
Hui Shi
Department of Gastroenterology, the Second Medical Center, the PLA General Hospital, Beijing 100853, China
Jun Wan
Shiping Xu
Liang Liao