Original Article
The plasma level of amyloid-β is associated with cognitive decline: a two years follow-up study in Xi′an rural areas
Junyi Li, Ling Gao, Shan Wei, Liangjun Dang, Suhang Shang, Chen Chen, Qiumin Qu
Published 2019-09-01
Cite as Chin J Intern Med, 2019, 58(9): 656-661. DOI: 10.3760/cma.j.issn.0578-1426.2019.09.005
Abstract
ObjectiveTo explore the relationship between plasma amyloid-β (Aβ) and cognitive decline during 2 year follow-up in a population-based cohort in Xi′an rural areas.
MethodsThe study was conducted in Qubao village in Xi′an suburbs cognitively normal residents over 40 years old were recruited from October 2014 to March 2015 and given a face-to-face standardized interview. Mini-mental state examination (MMSE) was employed to evaluate the global cognitive function, and quantification of plasma Aβ was measured by sandwich enzyme-linked immunosorbent assay (ELISA) at baseline. Two years later, MMSE was tested at the end of study. Then logistic regression was performed to analyze the relationship between baseline Aβ and cognitive change during 2 year follow-up.
ResultsA total of 1 020 participants completed the study, among whom 223 subjects (21.9%) presented MMSE scores decline (defined as MMSE scores decreased ≥2 points). Compared with those without decline, participants in the MMSE decline group were older (P<0.001) and had lower education level (P<0.001), while gender, hypertension, hyperlipemia, diabetes mellitus and APOE genotype were not significantly different between two groups. One-way analysis of variance (ANOVA) showed that the MMSE score decline was slighter in the lower tertile of baseline Aβ1-40 compared with middle tertile (P=0.012), while MMSE decline were similar between different Aβ1-42 level groups and Aβ1-42/Aβ1-40 ratio groups (P=0.758, P=0.671, respectively). Multivariable logistic regression analysis showed that MMSE scores in the lower baseline plasma Aβ1-40 level declined more slowly (OR=0.565, 95%CI 0.379-0.845, P=0.005). However, the MMSE decline were also similar among different baseline plasma Aβ1-42 levels groups and Aβ1-42/Aβ1-40 ratio groups.
ConclusionPopulation with lower level of baseline plasma Aβ1-40 manifests lower cognitive decline during 2 years, however further investigation on dynamics of plasma Aβ and long term follow up are needed.
Key words:
Alzheimer disease; Cognitive impairment; Plasma amyloid-β; Cohort studies
Contributor Information
Junyi Li
Department of Neurology, the First Affiliated Hospital of Xi′an Jiaotong University, Xi′an 710061, China
Ling Gao
Shan Wei
Liangjun Dang
Suhang Shang
Chen Chen
Qiumin Qu
