Original Article
Clinical characteristics of patients with Klebsiella pneumoniae pyogenic liver abscess
Xu Shuibao, Yang Siyu, Weng Shanshan, Chen Chen, Chen Shu, Zhang Wenhong, Jin Jialin
Published 2020-06-01
Cite as Chin J Intern Med, 2020, 59(6): 439-444. DOI: 10.3760/cma.j.cn112138-20190610-00403
Abstract
ObjectiveTo summarize the clinical features of patients with Klebsiella pneumoniae pyogenic liver abscess(KP-PLA).
MethodsClinical data of 133 patients with pyogenic liver abscess(PLA) and positive results of blood or pus culture were retrospectively analyzed in Huashan Hospital Affiliated to Fudan University from 2009 to 2018. According to the culture results, patients were divided into KP-PLA group (n=92) and non-KP-PLA group (n=41).
ResultsKP-PLA and non-KP-PLA were similar in gender composition with males accounting for 67.39% and 70.73%, and had age of (56.8±13.8) years and (55.0±13.0) years (χ2=0.146, 0.708, P>0.05) respectively. The underlying diseases were more common in KP-PLA group, including diabetes accounting for 45.65% and 24.39%, and hypertension accounting for 32.61% and 14.63% (χ2=5.384, 4.642, P<0.05) respectively. Patients with KP-PLA had more invasive infections beyond liver than those with non-KP-PLA, which were 27.17% and 9.76% (χ2=5.046, P=0.025). The laboratory results showed that hemoglobin levels in KP-PLA and non-KP-PLA were (109.88±20.97) g/L and (97.75±20.25) g/L (t=3.086, P=0.002). Serum alkaline phosphatase levels were 146.50 (114.50, 237.50) U/L and 220.50 (120.00, 316.75) U/L in KP-PLA and non-KP-PLA (U=2 239.500, P=0.048) patients.
ConclusionsKP-PLA mainly develops in middle-aged and elderly men, especially those with diabetes and hypertension. Patients with KP-PLA need to be paid more attention for invasive manifestations beyond liver.
Key words:
Liver abscess,pyogenic; Klebsiella pneumoniae; Clinical features
Contributor Information
Xu Shuibao
Department of Infectious Diseases, Huashan Hospital Affiliated to Fudan University, Shanghai 200040, China
Yang Siyu
Department of Infectious Diseases, Huashan Hospital Affiliated to Fudan University, Shanghai 200040, China
Weng Shanshan
Department of Infectious Diseases, Huashan Hospital Affiliated to Fudan University, Shanghai 200040, China
Chen Chen
Department of Infectious Diseases, Huashan Hospital Affiliated to Fudan University, Shanghai 200040, China
Chen Shu
Department of Infectious Diseases, Huashan Hospital Affiliated to Fudan University, Shanghai 200040, China
Zhang Wenhong
Department of Infectious Diseases, Huashan Hospital Affiliated to Fudan University, Shanghai 200040, China
Jin Jialin
Department of Infectious Diseases, Huashan Hospital Affiliated to Fudan University, Shanghai 200040, China
