Original Article
Surgical outcomes after laparoscopy-assisted distal gastrectomy and open distal gastrectomy for patients with advanced gastric cancer: a case-control study using a propensity score method
Jianxian Lin, Changming Huang, Chaohui Zheng, Ping Li, Jianwei Xie, Jiabin Wang, Jun Lu, Qiyue Chen, Longlong Cao, Mi Lin
Published 2016-10-01
Cite as Chin J surg, 2016, 54(10): 755-760. DOI: 10.3760/cma.j.issn.0529-5815.2016.10.007
Abstract
ObjectiveTo investigate the surgical outcomes after the laparoscopy-assisted distal gastrectomy (LADG) for patients with advanced gastric cancer.
MethodsThe data of 213 patients who underwent LADG and 213 treated by open distal gastrectomy (ODG) were selected using the propensity score matching method from a prospectively constructed database of 641 patients who underwent radical distal gastrectomy between January 2005 and June 2012 in Department of Gastric Surgery, Fujian Medical University Union Hospital. The baseline characteristics and surgical outcomes were compared using a paired t-test or the Wilcoxon signed ranks test for continuous variables. The cumulative survival rates were compared using the Kaplan-Meier method and log-rank test.
ResultsAmong all patients, there were significant differences in tumor location, digestive tract reconstruction, histologic type, pT stage, and pTNM stage between LADG and ODG group (P<0.05). After propensity score matching, patient distributions were closely balanced. There was no significant difference in clinicopathologic characteristics between the two groups (P>0.05). Regarding perioperative characteristics, the time to first flatus, and time to resumption of diet, did not differ between the two groups (P>0.05), while there were significant differences in the operation time (t=-11.28, P=0.000), blood loss (t=-5.674, P=0.000), number of dissected lymph nodes (t=4.727, P=0.000), and post-operative hospital stay (t=-2.193, P=0.038). LADG group has less morbidity than ODG group (χ2=4.777, P=0.029). Multivariate analysis revealed that the laparoscopic surgery (RR=0.392, P=0.009) was the protected factor for determining postoperative complications. There was no significant difference in the cumulative survival rate at total and each UICC stage between the two groups, either (P>0.05).
ConclusionLADG is an oncological safe minimally invasive procedure for advanced gastric cancer yields comparable oncological outcomes with ODG.
Key words:
Stomach neoplasms; Laparoscopy; Propensity score; Treatment outcome
Contributor Information
Jianxian Lin
Department of Gastric Surgery, Fujian Medical University Union Hospital, Fuzhou 350001, China
Changming Huang
Chaohui Zheng
Ping Li
Jianwei Xie
Jiabin Wang
Jun Lu
Qiyue Chen
Longlong Cao
Mi Lin
本文第757页表2腹腔镜组手术时间应为（185.2±57.3）min，开腹组应为（253.3±66.9）min，特此更正。