Fortum on Progress in Cariology and Endodontolgoy
Biological basis and clinical exploration of regenerative endodontic therapy
Zou Xiaoying, Yue Lin
Published 2022-01-09
Cite as Chin J Stomatol, 2022, 57(1): 3-9. DOI: 10.3760/cma.j.cn112144-20210928-00444
Abstract
Regenerative endodontic therapy is a tissue engineering based approach of treatment for endodontic disease. Its purpose is to achieve the regeneration of the pulp-dentin complex, thus to promote root development of the immature permanent tooth with necrotic pulp. Like other treatments based on tissue engineering techniques, the success of regenerative pulp therapy depends on such three elements as seed cells, scaffold materials and growth factors. Since its inception 20 years ago, there have been various terminologies in the literature, with similarities and differences in connotation. The present article summarizes and analyzes the term evolution, biological basis, clinical considerations and future scientific research directions of regenerative endodontics, in order to find out the unsolved scientific problems and to promote the development and standardization of this technique in clinical practice.
Key words:
Endodontics; Regenerative endodontic therapy; Tissue engineering; Stem cells
Contributor Information
Zou Xiaoying
Department of Cariology and Endodontology, Peking University School and Hospital of Stomatology &
National Center of Stomatology &
National Clinical Research Center for Oral Diseases &
National Engineering Research Center of Oral Biomaterials and Digital Medical Devices &
Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China
Yue Lin
Department of Cariology and Endodontology, Peking University School and Hospital of Stomatology &
National Center of Stomatology &
National Clinical Research Center for Oral Diseases &
National Engineering Research Center of Oral Biomaterials and Digital Medical Devices &
Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China
