Fractional amplitude analysis of low frequency fluctuation in alcohol dependent individuals : a resting state functional MRI study
YAN Ding-fang, CHEN Jun, LIU Jin-huan, ZHAO Yi-lin, LIN Xue, LIU Chang-sheng, QIU Li
Published 2012-09-10
Cite as Chin J Radiol, 2012,46(09): 798-802. DOI: 10.3760/cma.j.issn.1005-1201.2012.09.006
Abstract
Objective To explore brain activity features during the resting state in alcohol dependent individuals,and study the relationship between the brain activity features and alcohol dependent individuals' clinical symptoms.Methods Twenty-four alcohol dependent individuals and 22 healthy control subjects,well matched in gender,age,education and handedness,were enrolled as the alcohol dependent group and control group respectively.AGE 3.0 T MR scanner was used to acquire all the subjects' resting state data. DPARSF software was used to process resting functional MRI data,and then the whole brain fractional amplitudes of low frequency fluctuation (fALFF) data were acquired.Two-sample t test statistical analysis was made to access fALFF difference between the two groups. Results In comparison with the control group,the alcohol dependent group showed reduced fALFF in bilateral medial prefrontal gyrus,right inferior occipital gyrus,left precuneus,left inferior temporal gyrus,and left posterior lobe of cerebellum (0.64-1.69 vs.0.87-1.78,t =- 4.23- - 2.79,P < 0.05 ). fALFF was increased in the alcohol dependent group at the anterior cingulate,bilateral inferior frontal gyrus,right middle frontal gyrus,bilateral insular lobe,bilateral dorsal thalamus ( 0.86-1.82 vs. 0.76-1.58,t =3.56-3.96,P < 0.05 ).Conclusion Alcohol dependent individuals had abnormal activity at the bilateral prefrontal lobe,anterior cingulate,bilateral dorsal thalamus,bilateral insular lobe,left posterior lobe of cerebellum et al,during the resting state,and these abnormal activities might be related with clinical manifestation and pathophysiology.
Key words:
Alcoholism; Magnetic resonance imaging
Contributor Information
YAN Ding-fang
Department of Ultrasound, Taihe Hespital,Affiliated Hospital of Hubei Medicine University, Shiyan 442000, China
CHEN Jun
Department of Radiology, Renmin Hospital of Wuhan University, Wuhan 430060, China
LIU Jin-huan
Department of Radiology, Renmin Hospital of Wuhan University, Wuhan 430060, China
ZHAO Yi-lin
Department of Radiology, Renmin Hospital of Wuhan University, Wuhan 430060, China
LIN Xue
Department of Radiology, Renmin Hospital of Wuhan University, Wuhan 430060, China
LIU Chang-sheng
Department of Radiology, Renmin Hospital of Wuhan University, Wuhan 430060, China
QIU Li
Department of Radiology, Renmin Hospital of Wuhan University, Wuhan 430060, China