To evaluate the feasibility, safety and effectiveness of integrated treatment with comprehensively interventional techniques for acute deep venous thrombosis (DVT) of lower extremity.

During the period from June 2016 to June 2017, a total of 23 patients with acute DVT of unilateral lower extremity were admitted to authors' hospital to receive integrated treatment. AngioJet thrombectomy, balloon angioplasty and iliac vein stent implantation were performed in the same setting. Angiography was performed immediately after the procedure. If the thrombus clearance rate was grade Ⅲ and there were no large free clots (>5mm) in the lower extremity vein and inferior vena cava, the inferior vena cava filters would be retrieved through their sheath, otherwise, the inferior vena cava filters would be released. All patients received continuous transcatheter infusion of urokinase until the thrombosis was confirmed to be completely dissolved. The patients were followed up at outpatient clinic at 1, 3, 6 and 12 months after the treatment, and reexamination of color ultrasound and/or lower limb venography was used to assess the blood flow in the deep veins and in the stents.

Angiography postoperatively showed thrombus clearance rate of grade Ⅲ was obtained in 20 patients (87%) who were successfully accomplished integrated treatment. The inferior vena cava filters had been retrieved after thrombolysis in 3 patients (13%) with thrombus clearance rate of grade Ⅱ. Twenty-one stents were implanted directly after thrombectomy in 21 patients with iliac vein stenosis. There were no serious complications such as pulmonary embolism, severe hemorrhage, etc. Venous patency was confirmed by color ultrasound or lower limb venography.

Integrated treatment with comprehensively interventional techniques is feasible, safe, and effective for acute DVT of lower extremity.

Venous thrombosis; Lower extremity; Embolism and thrombosis; Thrombolytic therapy; Comprehensive interventional treatment