Gadoxetic Acid Application Research
The value of gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid enhanced T1 mapping MRI in the quantitative evaluation of hepatic fibrosis in patients with hepatitis B
Qiu Tian, Zhang Zhanqing, Chen Weibo, Huang Yangqing, Zhang Rengyin, Shi Yuxin, Ye Wen, Shi Xiudong, Lu Jian
Published 2019-12-10
Cite as Chin J Radiol, 2019,53(12): 1081-1085. DOI: 10.3760/cma.j.issn.1005-1201.2019.12.011
Abstract
ObjectiveTo investigate the quantitative evaluation efficiency of gadolinium- ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA) enhanced T1 mapping in staging hepatic fibrosis caused by viral hepatitis B.
MethodsOne hundred and fifty patients with chronic hepatitis B were prospectively enrolled in Shanghai Public Health Clinical Center, Fudan University from August 2016 to August 2018.These patients underwent liver aspiration biopsy were divided into four subgroups: S1 (n=38), S2 (n=30), S3 (n=33), S4 (n=49) according to Scheuer-Ludwig scoring system. Non-enhanced and Gd-EOB-DTPA-enhanced MRI were performed in all subjects. Look-Locker sequences were performed to acquire T1 mapping of pre and post-contrast at 20 minutes after Gd-EOB-DTPA administration. The T1 value after 20 minutes of Gd-EOB-DTPA administration (T1 20 min), the reduction rate of T1 value (ΔT1 20 min%), the increase of 1/T1 value (ΔR1 20 min%) were measured and calculated. The one-way ANOVA was applied to compare the difference in T1 20 min, ΔT1 20 min%, ΔR1 20 min% of various fibrosis stages. ROC curves were used to assess the efficacy of T1 20 min, ΔT1 20 min%, ΔR1 20 min% for diagnosing ≥ S2, ≥ S3, ≥ S4. P<0.05 was considered to be statistically significant.
ResultsThe T1 20 min raised with fibrosis stage increased, ΔT1 20 min% and ΔR1 20 min% reduced with fibrosis stage increased. Areas under the curves of T1 20 min, ΔT1 20 min%, ΔR1 20 min% for diagnosing ≥ S2 were 0.844, 0.905, 0.869; and diagnosing ≥ S3 were 0.832, 0.907, 0.862; and diagnosing ≥ S4 were 0.853, 0.897, 0.873, respectively. The diagnostic efficiency of ΔT1 20 min% was the best.
ConclusionGd-EOB-DTPA-enhanced T1 mapping could be regarded as a reliable diagnostic tool for the evaluation of hepatic fibrosis caused by viral hepatitis B.
Key words:
Hepatic fibrosis; Magnetic resonance imaging; Gadoxetate acid disodium; T1 mapping
Contributor Information
Qiu Tian
Department of Radiology, Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China
Zhang Zhanqing
Department of Hepatology, Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China
Chen Weibo
Philips Healthcare, Shanghai 200040, China
Huang Yangqing
Department of Hepatobiliary Surgery, Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China
Zhang Rengyin
Department of Radiology, Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China
Shi Yuxin
Department of Radiology, Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China
Ye Wen
Department of Radiology, Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China
Shi Xiudong
Department of Radiology, Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China
Lu Jian
Department of Radiology, Third People′s Hospital of Nantong, Nantong 226006, China