Health Impacts of Air Pollution and Climate Change
The study on the association of long-term ambient fine particulate matters exposure and elevated blood pressure in children
Mi Xin, Zhang Yunting, Hu Liwen, Liu Kangkang, Yang Boyi, Zeng Xiaowen, Guo Yuming, Dong Guanghui
Published 2019-01-06
Cite as Chin J Prev Med, 2019,53(1): 45-50. DOI: 10.3760/cma.j.issn.0253-9624.2019.01.005
Abstract
ObjectiveTo evaluate the association of long-term ambient fine particulate matters (PM2.5) exposure with elevated blood pressure in children.
MethodsFrom April 2012 to June 2013, we used cluster randomized sampling method to investigate 9 354 children aged 5-17 years old from 68 primary and middle schools in the seven Northeastern Cities (Shenyang, Dalian, Fushun, Anshan, Benxi, Liaoyang and Dandong) in Liaoning Province, and measured their blood pressure (BP). A spatial statistical model nested by aerosol optical depth (AOD) was used to inverse PM2.5 concentrations. Generalized additive model was used to quantify the association between PM2.5 exposure and blood pressure in children. To examine the associations, two-level regression model was used to evaluate individual characteristics′ modifying effect on the health influence of PM2.5.
ResultsThe prevalence of hypertension in children was 13.78% (1 289/9 354). The results showed that there was an associations between hypertension and pollutants, and the multivariable regression analysis indicated that the increase in mean systolic blood pressure (SBP), diastolic blood pressure (DBP), and the OR of hypertension associated with a 10 μg/m3 increase for PM2.5 were 3.12 (95%CI: 2.71-3.54) mmHg (1 mmHg=0.133 kPa), 1.45 (95%CI:1.12-1.78) mmHg, and 1.55 (95%CI: 1.10-2.19), respectively. Compared with non-breastfeeding children (OR=2.10, 95%CI: 1.39-3.17), children who were breastfeeding (OR=1.49, 95%CI: 1.00-2.20) exhibited consistently weaker effects, and the interaction effect of P value was 0.002.
ConclusionStudy findings indicate that long-term exposure to PM2.5 is associated with increased arterial BP and hypertension among the children. Breastfeeding may reduce this association.
Key words:
Blood pressure; Child; PM2.5
Contributor Information
Mi Xin
School of Public Health, Sun Yat-sen University/Guangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk Assessment, Guangzhou 510080, China
Zhang Yunting
School of Public Health, Sun Yat-sen University/Guangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk Assessment, Guangzhou 510080, China
Hu Liwen
School of Public Health, Sun Yat-sen University/Guangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk Assessment, Guangzhou 510080, China
Liu Kangkang
School of Public Health, Sun Yat-sen University/Guangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk Assessment, Guangzhou 510080, China
Yang Boyi
School of Public Health, Sun Yat-sen University/Guangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk Assessment, Guangzhou 510080, China
Zeng Xiaowen
School of Public Health, Sun Yat-sen University/Guangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk Assessment, Guangzhou 510080, China
Guo Yuming
School of Public Health and Preventive Medicine, Monash University, Melbourne VIC3004, Australia
Dong Guanghui
School of Public Health, Sun Yat-sen University/Guangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk Assessment, Guangzhou 510080, China