Criterion•Guideline•Consensus
Expert consensus on rabies exposure prophylaxis
Yin Wenwu, Wang Chuanlin, Chen Qiulan, Dong Guanmu, Li Yuhua, Zhu Wuyang, Liu Si, Chen Qingjun, Lyu Xinjun, Zhu Zhenggang, Tao Xiaoyan, Li Yu, Mou Di, Wang Xianjun
Published 2019-07-06
Cite as Chin J Prev Med, 2019, 53(7): 668-679. DOI: 10.3760/cma.j.issn.0253-9624.2019.07.004
Abstract
Rabies is a zoonotic infectious disease caused by lyssavirus and characterized by central nervous system symptoms. The fatality rate of rabies is almost 100%. About 59 000 cases die of rabies worldwide every year, mainly in Asia and Africa. China is an epidemic country of rabies. Grade II and III exposures are the main types of rabies exposures in China. Standardized post-exposure prophylaxis (PEP) can prevent rabies almost 100%. Human Rabies Vaccine Technical Working Group, National Immunization Advisory Committee and invited experts reached an expert consensus on PEP by referring to the World Health Organization′s position paper on rabies vaccine in 2018 and related research progress in recent.
Key words:
Rabies; Lyssavirus; Post-exposure prophylaxis; Vaccine; Immunoglobulin
Contributor Information
Yin Wenwu
Infectious Disease Management Department, Chinese Center for Disease Control and Prevention, Beijing 102206, China
Wang Chuanlin
Emergency Department/Trauma Center, Peking University People′s Hospital, Beijing 100044, China
Chen Qiulan
Infectious Disease Management Department, Chinese Center for Disease Control and Prevention, Beijing 102206, China
Dong Guanmu
Department of Arboviruses and Rabies, National Institute for Food and Drug Control, Beijing 102629, China
Li Yuhua
Department of Arboviruses and Rabies, National Institute for Food and Drug Control, Beijing 102629, China
Zhu Wuyang
Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China
Liu Si
Emergency Department, First Hospital of Peking University, Beijing 100034, China
Chen Qingjun
Emergency Department, Beijing Hepingli Hospital, Beijing 100013, China
Lyu Xinjun
Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China
Zhu Zhenggang
Rabies Clinic, Wuhan Center for Disease Control and Prevention, Wuhan 430015, China
Tao Xiaoyan
Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China
Li Yu
Infectious Disease Management Department, Chinese Center for Disease Control and Prevention, Beijing 102206, China
Mou Di
Infectious Disease Management Department, Chinese Center for Disease Control and Prevention, Beijing 102206, China
Wang Xianjun
Institute for Viral Disease Control and Prevention, Shandong Center for Disease Control and Prevention, Jinan 250014, China
