Criterion•Guideline•Consensus
Expert consensus on rabies exposure prophylaxis
Wenwu Yin, Chuanlin Wang, Qiulan Chen, Guanmu Dong, Yuhua Li, Wuyang Zhu, Si Liu, Qingjun Chen, Xinjun Lyu, Zhenggang Zhu, Xiaoyan Tao, Yu Li, Di Mou, Xianjun Wang
Published 2019-07-06
Cite as Chin J Prev Med, 2019, 53(7): 668-679. DOI: 10.3760/cma.j.issn.0253-9624.2019.07.004
Abstract
Rabies is a zoonotic infectious disease caused by lyssavirus and characterized by central nervous system symptoms. The fatality rate of rabies is almost 100%. About 59 000 cases die of rabies worldwide every year, mainly in Asia and Africa. China is an epidemic country of rabies. Grade II and III exposures are the main types of rabies exposures in China. Standardized post-exposure prophylaxis (PEP) can prevent rabies almost 100%. Human Rabies Vaccine Technical Working Group, National Immunization Advisory Committee and invited experts reached an expert consensus on PEP by referring to the World Health Organization′s position paper on rabies vaccine in 2018 and related research progress in recent.
Key words:
Rabies; Lyssavirus; Post-exposure prophylaxis; Vaccine; Immunoglobulin
Contributor Information
Wenwu Yin
Infectious Disease Management Department, Chinese Center for Disease Control and Prevention, Beijing 102206, China
Chuanlin Wang
Emergency Department/Trauma Center, Peking University People′s Hospital, Beijing 100044, China
Qiulan Chen
Infectious Disease Management Department, Chinese Center for Disease Control and Prevention, Beijing 102206, China
Guanmu Dong
Department of Arboviruses and Rabies, National Institute for Food and Drug Control, Beijing 102629, China
Yuhua Li
Department of Arboviruses and Rabies, National Institute for Food and Drug Control, Beijing 102629, China
Wuyang Zhu
Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China
Si Liu
Emergency Department, First Hospital of Peking University, Beijing 100034, China
Qingjun Chen
Emergency Department, Beijing Hepingli Hospital, Beijing 100013, China
Xinjun Lyu
Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China
Zhenggang Zhu
Rabies Clinic, Wuhan Center for Disease Control and Prevention, Wuhan 430015, China
Xiaoyan Tao
Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China
Yu Li
Infectious Disease Management Department, Chinese Center for Disease Control and Prevention, Beijing 102206, China
Di Mou
Infectious Disease Management Department, Chinese Center for Disease Control and Prevention, Beijing 102206, China
Xianjun Wang
Institute for Viral Disease Control and Prevention, Shandong Center for Disease Control and Prevention, Jinan 250014, China
