Original Article
Clinicopathological features of diffuse pulmonary meningotheliomatosis
Hongmei Wu, Ping Mei, Xiaolan Zhu, Fen Zhang, Chao Liu, Hui Liu, Zebin Xiao, Yu Chen, Yanhui Liu, Zhi Li
Published 2019-06-08
Cite as Chin J Pathol, 2019, 48(6): 444-447. DOI: 10.3760/cma.j.issn.0529-5807.2019.06.004
Abstract
ObjectiveTo study the clinicopathological characteristics, immunophenotype, pathologic diagnosis and differential diagnosis of diffuse pulmonary meningotheliomatosis (DPM).
MethodsThe clinical data, histological features and immunohistochemical results of three cases of DPM collected from January 2016 to May 2018 at Guangdong Provincial People′s Hospital were analyzed, and the relevant literature reviewed.
ResultsThe three DPM patients age was 53, 69 and 74 years. The lesions consisted of multiple minute pulmonary meningothelial-like nodules profusely involving the lungs. Microscopically, they showed typical morphology, characterized by medium-sized elongated tumor cells resembling meningothelial cells with whorled/nested clusters. The cells were uniform and had abundant eosinophilic cytoplasm with oval nuclei with delicate chromatin. Immunohistochemical staining showed tumor cells were diffusely and strongly positive for EMA, vimentin and PR, but were negative for CAM5.2, CgA, Syn, CK7 and TTF1.
ConclusionsDPM is extremely rare, and may be confused with primary interstitial pulmonary processes and metastatic malignant tumors of lung. Recognition of this entity is essential for pathologists to avoid misdiagnosis and unnecessary treatment.
Key words:
Lung diseases; Multiple pulmonary nodules; Diagnosis, differential; Immunohistochemistry; Diffuse pulmonary meningotheliomatosis
Contributor Information
Hongmei Wu
Department of Pathology, Guangdong Provincial People′s Hospital
Guangdong Academy of Medical Sciences, Guangzhou 510080, China
Ping Mei
Department of Pathology, Guangdong Provincial People′s Hospital
Guangdong Academy of Medical Sciences, Guangzhou 510080, China
Xiaolan Zhu
Department of Pathology, Guangdong Provincial People′s Hospital
Guangdong Academy of Medical Sciences, Guangzhou 510080, China
Fen Zhang
Department of Pathology, Guangdong Provincial People′s Hospital
Guangdong Academy of Medical Sciences, Guangzhou 510080, China
Chao Liu
Department of Pathology, Guangdong Provincial People′s Hospital
Guangdong Academy of Medical Sciences, Guangzhou 510080, China
Hui Liu
Department of Imaging, Guangdong Provincial People′s Hospital
Guangdong Academy of Medical Sciences, Guangzhou 510080, China
Zebin Xiao
Department of Pathology, Guangdong Provincial People′s Hospital
Guangdong Academy of Medical Sciences, Guangzhou 510080, China
Yu Chen
Department of Pathology, Guangdong Provincial People′s Hospital
Guangdong Academy of Medical Sciences, Guangzhou 510080, China
Yanhui Liu
Department of Pathology, Guangdong Provincial People′s Hospital
Guangdong Academy of Medical Sciences, Guangzhou 510080, China
Zhi Li
Department of Pathology, Guangdong Provincial People′s Hospital
Guangdong Academy of Medical Sciences, Guangzhou 510080, China