Original Articles
Effects of preoperative aspirin therapy on early postoperative outcomes in elderly patients undergoing off-pump coronary artery bypass surgery
Dong An, Qingliang Chen, Lianqun Wang, Nan Jiang, Qiang Wang, Zhigang Guo
Published 2015-04-14
Cite as Chin J Geriatr, 2015, 34(4): 374-377. DOI: 10.3760/cma.j.issn.0254-9026.2015.04.009
Abstract
ObjectiveTo analyze the benefits and risks of preoperative aspirin treatment in elderly patients undergoing off-pump coronary artery bypass(OPCAB) grafting.
MethodsFrom January 2010 to June 2014 in Tianjin Chest Hospital, 1 501 consecutive patients aged >65 years with mean age (71.1±4.2) years who underwent selective first-time isolated off-pump coronary artery bypass surgery were included in this research. They were divided into 2 groups: aspirin group (long-term use of entericcoated-aspirin tablets within 5 days before operation, n=369) and aspirin withdrawal group (aspirin withdrawal for 5 days and over before operation, n=1 132). Univariate analysis and a logistic regression were used to compare the postoperative events between the two groups. To adjust for the remaining differences between groups, propensity score was enrolled into the logistic regression model.
ResultsThere were no significant differences between the two groups in all-cause in-hospital mortality, postoperative myocardial infarction, cerebrovascular events, postoperative renal failure, blood dialysis and reoperation for bleeding (all P>0.05), but more frequency of red blood cell transfusions were found in aspirin group than in aspirin withdrawal group 〔74.0%(273/369)vs.62.5%(707/1 132), adjusted OR=1.50, 95%CI: 1.13-2.00, P<0.01〕.
ConclusionsPreoperative aspirin treatment can increase the incidence of red blood cell transfusion, but cannot increase the incidence of reoperation for bleeding, and has no effect on the postoperative outcomes such as all-cause in-hospital mortality, cerebrovascular events, postoperative myocardial infarction, postoperative renal failure or blood dialysis in patients undergoing selective isolated OPCAB.
Key words:
Aspirin; Off-pump, coronary artery bypass grafting
Contributor Information
Dong An
Graduate School of Tianjin Medical University, Tianjin 300070, China
Qingliang Chen
Lianqun Wang
Nan Jiang
Qiang Wang
Zhigang Guo