To assess the clinical effects of Ipratropium bromide combined with atomization inhalation of budesonide via a ventilator with a Y-shaped connector on acute exacerbation of chronic obstructive pulmonary disease (AECOPD).

A total of 62 AECOPD patients treated at our hospital from June 2013 to September 2014 were randomly divided into the experimental group (n=31, treated with ipratropium bromide combined with atomization inhalation of budesonide) and the control group (n=31, treated with the same amount of saline).

The airway pressure of mechanical ventilation, the time of mechanical ventilation and the time of staying in the intensive care unit all showed significant differences between the experimental and control groups 〔(25.4±5.2) cmH₂O vs. (38.1±3.4) cmH₂O, (6.5±1.3) d vs. (6.8±1.4) d, (8.9±2.1) d vs. (9.5±1.5) d, t=10.934, 0.960, 1.108, respectively, P<0.05 for all〕. The rate of tracheotomy was lower in the experimental group than in the control group (17/31 or 54.8% vs. 20/31 or 64.5%, χ²=0.603, P<0.05).

Ipratropium bromide combined with budesonide inhalation under mechanical ventilation via a Y-shaped connector has favorable clinical effects on AECOPD.

Pulmonary disease, chronic obstructive; Ipratropium; Budesonide; Ventilators, negative-pressure