Original Article
Effect of Chinese version of"Reading the Mind in the Eyes"test on the diagnosis of mild cognitive impairment and Alzheimer's dementia
Ma Jie, Guo Qihao, Zhang Yunyun, He Mengqi
Published 2015-11-14
Cite as Chin J Geriatr, 2015, 34(11): 1218-1222. DOI: 10.3760/cma.j.issn.0254-9026.2015.11.018
Abstract
ObjectiveTo investigate the effect of the revision of Chinese Versions of"Reading the Mind in the Eyes"Test(RME) on the diagnosis of mild cognitive impairment (MCI) and mild Alzheimer's dementia (AD).
MethodsWe compared performance on the cognitive test battery between 96 patients with MCI and 55 patients with AD and 95 control individuals. Neuropsychological tests, encompassing RME-T, Mini Mental State Examination (MMSE) and Auditory Verbal Learning Test (AVLT), were conducted on 96 patients with MCI, 55 patients with AD and 95 healthy control individuals. Completion rate of RME-T in the normal group and the total scores and each item score of RME-T were analyzed, and the feature between RME-T and RME-S (RME-short) was compared.
ResultsThe total score of RME-T was (23.7±4.7) in normal group, (19.9±4.9) in MCI group, and (19.9±7.5) in AD group. There were significant differences in the total score of RME-T among the three groups (t=13.9, P<0.01). The differences in the total score of RME-T between normal group and AD group, between normal group and MCI group were also significant (bothP<0.01). RME-S was composed of 20 items after rejecting 16 items of RME-T whose project completion rate was lower than 50% in the normal group and in which there was no significant difference among normal, MCI and AD groups. The correlations between the total score of RME-T and 3 item scores of RME-T were not significant (P>0.05). However, the total score of RME-S was highly correlated with each item score of RME-S (P<0.01). The total score of RME-T and RME-S were highly correlated with each total score of the cognitive test battery (P<0.01). With the normal and MCI groups, normal and AD groups as the subjects, the receiver operating characteristic (ROC) curve analysis found that AUC(RME-S) was>AUC(RME-T) in normal and AD groups (P<0.01), whereas, AUC(RME-S) was<AUC(RME-T) in normal and MCI groups (P>0.05).
ConclusionsRME has good reliability and validity, and RME-S is better than RME-T in internal consistency, which is more suitable for identifying mild cognitive impairment and Alzheimer's disease in Chinese population, and it is worthy of further popularization and application.
Key words:
Neuropsychological tests; Cognition disorders; Alzheimer disease
Contributor Information
Ma Jie
Stroke Unit, Department of Neurology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China
Guo Qihao
Zhang Yunyun
He Mengqi
