Original Article
Relationship between benign prostatic hyperplasia and renal function in men aged 80 years and over
Qian Wang, Shengnan Yang, Qianru Zhao, Bing Li, Xin Li, Rui Tian, Zhangsuo Liu
Published 2018-03-14
Cite as Chin J Geriatr, 2018, 37(3): 284-287. DOI: 10.3760/cma.j.issn.0254-9026.2018.03.010
Abstract
ObjectiveTo explore the relationship between benign prostatic hyperplasia and renal function in men aged 80 years and over.
MethodsEighty-three clinical BPH patients (mean age of 85.8±4.7 years, range of 80-98 years) admitted to Geriatric Department of the First Affiliated Hospital of Zhengzhou University were recruited to this cross-sectional study from January 2017 to June 2017. They were grouped into treatment group (Gt, n=43) and non-treatment group (Gn, n=40) based on their choices for a therapy or observation.The prostate volume(PV) and post-void residual urine volume (PVR) were measured by abdominal ultrasound. A self-reported lower urinary tract symptoms (LUTS) was evaluated by International Prostate Symptoms Score (IPSS). An estimated glomerular filtration rate (eGFR) was calculated based on the serum level of creatinine and other indexes. Spearman and multiple linear regression analysis were applied to analyze correlations between BPH and renal function.
ResultsThe systolic and diastolic blood pressures were lower in Gt group than in Gn group (all P<0.05). The PVR and IPSS were significantly lower in Gt group than in Gngroup[(28.9±16.6) ml vs.(67.3±32.8) ml; (18.2±9.1)vs.(24.7±10.3), all P<0.05]. The serum level of creatinine was lower in Gt group [(73.7±16.3) μmol/L] than in Gn group[(85.4±19.8) μmol/L] (P<0.05). The eGFR was higher in Gt group[(77.2±11.4) ml·min-1·1.73 m-2] than in Gn group[(69.8±13.9) ml·min-1·1.73 m-2] (P<0.05). No statistical differences were observed in PV between Gt group[(24.6±11.4) ml] and Gn group[(27.0±20.8) ml] (P>0.05). Spearman relation analysis showed that creatinine level was negatively correlated with treatment for BPH (r=-0.337, P<0.05). Multiple linear regression analysis showed that non-receiving of treatments for BPH was an independent risk factor for an increased creatinine level(r=-0.349, t=-2.802, P<0.01).
ConclusionsFor men aged 80 years and over, BPH is associated with decreased eGFR, and the treatment for BPH may improve renal function.
Key words:
Prostatic hyperplasia; Kidney
Contributor Information
Qian Wang
Department of Geriatric Medicine, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
Shengnan Yang
Department of Geriatric Medicine, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
Qianru Zhao
Department of Geriatric Medicine, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
Bing Li
Department of Geriatric Medicine, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
Xin Li
Department of Geriatric Medicine, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
Rui Tian
Department of Geriatric Medicine, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
Zhangsuo Liu
Department of Nephrology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
