Original Article
Efficacy of Broncho-Vaxom on chronic obstructive pulmonary disease in elderly patients
Dunhuang Zeng, Jiefeng Huang, Biying Wang, Gongping Chen
Published 2019-07-14
Cite as Chin J Geriatr, 2019, 38(7): 717-721. DOI: 10.3760/cma.j.issn.0254-9026.2019.07.002
Abstract
ObjectiveTo evaluate the efficacy of the bacterial lysate Broncho-vaxom on chronic obstructive pulmonary disease(COPD)in elderly patients.
MethodsA total of 150 patients with stable COPD were randomized into the Broncho-vaxom group(n=78)treated with Broncho-vaxom as add-on to conventional treatment and the control group(n=72)treated with conventional treatment.The number of acute exacerbation of COPD per patient per year, quality of life, lung function, T cell subsets were evaluated for the therapeutic effects.
ResultsAfter one year of treatment, the number of acute exacerbation per patient per year was lower in Broncho-vaxom group than in control group[(1.44±1.05)times/y vs.(1.82±0.61)times/y, t=2.754, P=0.007]. The proportions of acute exacerbation-free patients were higher in Broncho-vaxom group than in control group(20.5% or 16/78 vs.4.2% or 3/72, χ2=9.043, P=0.003). There were significant differences in the forced vital capacity(FVC), forced expiratory volume in one second(FEV1), and forced expiratory volume in one second/predicted value ratio(FEV1%)between the two groups at 5 different time points(before, at 3, 6, 9 and 12 months after treatment)(Broncho-vaxom group: F=90.819, 50.674 and 51.233, P=0.000; control group: F=84.928, 90.654 and 86.117, P=0.000). After treatment, the symptom scores were lower in Broncho-vaxom group than in control group, and the ratios of CD4/CD8 T-cell were increased and level of CD8 T-cell was decreased in Broncho-vaxom group(all P<0.05). The rate of adverse reactions had no significant difference between Broncho-vaxom group and control group(3/78 or 3.8% vs.2/72 or 2.8%, χ2=0.132, P=0.717).
ConclusionsThe oral administration of Broncho-vaxom for six months can modulate and enhance immune functions, significantly decrease acute exacerbation frequency, improve quality of life and delay the deterioration in lung function in elderly patients with stable COPD.
Key words:
Pulmonary disease, chronic obstructive; Immunity , cellular
Contributor Information
Dunhuang Zeng
Department of Respiratory Disease, the First Affiliated Hospital, Fujian Medical University, Fuzhou 350005, China
Jiefeng Huang
Biying Wang
Gongping Chen