Objective To study the shielding effect of equivalent thickness and size of lead glasses on eye lens of interventional radiologists.Methods Based on the human voxel phantom and MCNPX software,doses to eye lens of radiologists were simulated under different conditions of wearing lead glasses and beam projections,and measurements were performed with anthropomorphic phantom placed with eye lens dosimeters to verify simulation results.Results The results showed that the dose to eye lens reduced by a factor from 3 to 9 when the equivalent thickness of glasses ranged from 0.1 to 1.0 mm Pb with a len size of 20 cm2.The dose reduction factors (DRF) not only depended on the lead equivalent,but also on the beam projection of X-rays.However,the increase in DRF was not significant whenever the lead equivalent of glasses was larger than 0.35 mm.Furthermore,the DRF was proportional to the size of glass lens from 6 to 30 cm2 with the same lead equivalent.The simulation results were in well agreement with the measured ones.Conclusions For more reasonable and effective protection of the eye lens of interventional radiologists,a pair of glasses with a lead equivalent of 0.5 mm and large-sized lens is recommended.