Radiotherapy
Analysis of memory function and MRI changes in nasopharyngeal carcinoma patients after radiotherapy
Tieming Xie, Yue Kong, Lei Shi, Fenglei Du, Shuang Huang, Yonghong Hua, Qiaoying Hu, Ting Jin, Xiaozhong Chen, Yuanyuan Chen
Published 2018-02-25
Cite as Chin J Radiol Med Prot, 2018, 38(2): 105-109. DOI: 10.3760/cma.j.issn.0254-5098.2018.02.005
Abstract
ObjectiveTo analyse the memory function and MRI changes in local-advanced nasopharyngeal carcinoma patients before- and after- radiation.
MethodsClinical data, dosimetric data, digital span score and MRI of 14 cases with nasopharyngeal carcinom treated in Zhejiang Cancer Hospital from November 2015 to August 2016 were retrospectively analysed. There were 1 case at T2 stage, 7 cases at T3 and 6 at T4. They received IMRT or TOMO therapy concurrent with 2 cycles Nedaplatin after 2-3 cycles PF/TP induction chemotherapy.
ResultsThe IMRT dosimetric data of 9 cases were available. For hippocampus and temporal lobe, the mean volume was (15.17±2.17) and (95.07±12.26) cm3, respectively, while the mean dose was (1 154.06±771.63) and (1 306.61±603.69) Gy, and the max dose (3 797.61±1 450.98) and (5 394.17±982.28) Gy, respectively. The equivalent uniform dose (EUD) was (2 233.28±872.73) Gy for hippocampus and (3 113.11±603.69) Gy for temporal lobe. 10 patients received digit span score before- and 3 months after- radiotherapy. The mean score of forward digit span was 8.8±1.8 before radiation and 8.1±1.59 at 3 months after radiation(P>0.05), while that of backward digit span decreased from 6.2±1.04 before radiation to 5.3±2.36 at 3 months after radiation (t=3.25, P<0.05). 9 patients’ MRI were available. Volume reduction of temporal lobe was observed(t=4.57, P<0.01)by voxel-based morphometry (VBM).
ConclusionsRadiation-induced injury to hippocampus and temporal lobe is inevitable in local-advanced nasopharyngeal carcinoma patients. There might be some connection between memory loss and temporal lobe volume atrophy after radiotherapy. Enrollment of larger sample analysis is expected.
Key words:
Nasopharyngeal carcinoma; Radiation-induced injury; Hippocampus; Temporal lobe; MRI
Contributor Information
Tieming Xie
Department of Radiology, Zhejiang Cancer Hospital, Hangzhou 310022, China
Yue Kong
Department of Radiation Oncology, Zhejiang Cancer Hospital, Hangzhou 310022, China
Lei Shi
Department of Radiology, Zhejiang Cancer Hospital, Hangzhou 310022, China
Fenglei Du
Department of Radiation Oncology, Zhejiang Cancer Hospital, Hangzhou 310022, China
Shuang Huang
Department of Radiation Oncology, Zhejiang Cancer Hospital, Hangzhou 310022, China
Yonghong Hua
Department of Radiation Oncology, Zhejiang Cancer Hospital, Hangzhou 310022, China
Qiaoying Hu
Department of Radiation Oncology, Zhejiang Cancer Hospital, Hangzhou 310022, China
Ting Jin
Department of Radiation Oncology, Zhejiang Cancer Hospital, Hangzhou 310022, China
Xiaozhong Chen
Department of Radiation Oncology, Zhejiang Cancer Hospital, Hangzhou 310022, China
Yuanyuan Chen
Department of Radiation Oncology, Zhejiang Cancer Hospital, Hangzhou 310022, China
