Vaccine evaluation-Varicella vaccine
Immunogenicity and safety of co-immunization of children with live attenuated varicella-zoster virus vaccine and live attenuated hepatitis A virus vaccine
Jin Xu, Hongjie Shen, Jun Li, Wanyu Lyu, Yanli Ma, Sheng Zhao, Qingxiao Huang, Yingjie Wang, Min Zhang, Ying Ye, Yonghao Guo, Yanyang Zhang, Bin Xu, Haiping Chen
Published 2016-03-31
Cite as Chin J Microbiol Immunol, 2016, 36(3): 197-201. DOI: 10.3760/cma.j.issn.0254-5101.2016.03.007
Abstract
ObjectiveTo investigate the immunogenicity and safety of co-immunization of children with live attenuated varicella-zoster virus (VZV) vaccine and live attenuated hepatitis A virus (HAV) vaccine.
MethodsA total of 686 children aged 18-24 months were recruited in Henan province of China and divided into three groups. Children in the three groups were respectively immunized with live attenuated VZV vaccine or live attenuated HAV vaccine alone or in combination. Blood samples were collected from all subjects before and one month after vaccination for the detection of seroconversion and seropositive rates. Occurrence of adverse events was monitored for safety evaluation. Antibody membrane immune-fluorescence assay and enzyme immunoassay were performed to detect the antibodies against VZV and HAV, respectively.
ResultsThe seroconversion rates of anti-VZV antibody were both 100% in children received co-immunization or VZV vaccine immunization alone. The geometric mean titer (GMT) of anti-VZV antibody in co-immunization group was higher than that of VZV vaccine immunization group (P<0.001). The GMT and seroconversion rate of anti-HAV antibody in children immunized with live attenuated VZV vaccine and live attenuated HAV vaccine were similar to those immunized with live attenuated HAV vaccine alone (P=0.94, P=0.77). Adverse reactions were reported in 156 subjects with a rate of 22.74%, mainly manifested as fever and swelling. No other adverse reactions were observed. No significant differences in the adverse events were observed between the three groups.
ConclusionCo-immunization children with live attenuated varicella vaccine and live attenuated hepatitis A virus vaccine provided equivalent immunogenicity and safety in comparison with immunization the two vaccines alone, indicating the feasibility of co-immunization strategy.
Key words:
Live attenuated varicella vaccine; Live attenuated hepatitis A virus vaccine; Co-immunization; Immunogenicity; Safety
Contributor Information
Jin Xu
Henan Centre for Disease Control and Prevention, Zhengzhou 450016, China
Hongjie Shen
Changchun Keygen Biological Products Co. Ltd, Changchun 130012, China
Jun Li
Henan Centre for Disease Control and Prevention, Zhengzhou 450016, China
Wanyu Lyu
Henan Centre for Disease Control and Prevention, Zhengzhou 450016, China
Yanli Ma
China National Biotec Group Company Limited, Beijing 100029, China
Sheng Zhao
Henan Centre for Disease Control and Prevention, Zhengzhou 450016, China
Qingxiao Huang
China National Biotec Group Company Limited, Beijing 100029, China
Yingjie Wang
Changchun Keygen Biological Products Co. Ltd, Changchun 130012, China
Min Zhang
China National Biotec Group Company Limited, Beijing 100029, China
Ying Ye
Henan Centre for Disease Control and Prevention, Zhengzhou 450016, China
Yonghao Guo
Henan Centre for Disease Control and Prevention, Zhengzhou 450016, China
Yanyang Zhang
Henan Centre for Disease Control and Prevention, Zhengzhou 450016, China
Bin Xu
China National Biotec Group Company Limited, Beijing 100029, China
Haiping Chen
China National Biotec Group Company Limited, Beijing 100029, China