Review
Roles of inflammatory cytokines in acute graft-versus-host disease and their mechanisms
Shuangzhu Liu, Shoubao Ma, Haiyan Liu, Depei Wu
Published 2017-01-31
Cite as Chin J Microbiol Immunol, 2017, 37(1): 78-82. DOI: 10.3760/cma.j.issn.0254-5101.2017.01.013
Abstract
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an effective therapy for the treatment of various malignant and non-malignant hematological diseases. Acute graft-verse-host-disease (aGVHD), a major complication following allo-HSCT, is one of the predominant causes of GVHD-related mortality. The development of aGVHD is a typical pathologic process with the release of inflammatory cytokines in great quantities, resulting in the occurrence of " cytokine storm" and causing specific pathological damages by attacking the recipient organ. Therefore, identification of biomarkers specific for aGVHD offers promise to the treatment of aGVHD. In this review, we summarizes the functions of several typical inflammatory cytokines, including IL-1β, IL-6, IL-17A and IL-10, and their mechanisms in the development of aGVHD in order to provide references for the prevention and treatment of aGVHD.
Key words:
aGVHD; Proinflammator factor; Suppressive factor; Biomarkers; Predictive value
Contributor Information
Shuangzhu Liu
Institute of Blood and Marrow Transplantation, Department of Hematology
the First Affiliated Hospital of Soochow University
Jiangsu Institute of Hematology and Key Laboratory of Thrombosis and Hemostasis, National Health and Family Planning Commission
Collaborative Innovation Center of Hematology, Suzhou 215006, China
Shoubao Ma
Haiyan Liu
Depei Wu
