Epidemiology Investigation
Clinical and molecular characteristics of invasive community-acquired methicillin-resistant Staphylococcus aureus infection in Chinese neonates
Geng Wenjing, Dong Fang, Weng Jingwen, Dong Shixiao, Jin Fei, Shen Xuzhuang, Qi Yujie
Published 2017-07-31
Cite as Chin J Microbiol Immunol, 2017,37(07): 552-556. DOI: 10.3760/cma.j.issn.0254-5101.2017.07.013
Abstract
ObjectiveTo analyze the clinical and molecular features of community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) infection in neonates and to investigate their antibiotic resistance profiles.
MethodsA total of 35 invasive CA-MRSA strains were collected from six hospitals in 2014. Multilocus sequence typing (MLST), staphylococcal cassette chromosome mec (SCCmec) typing and spa typing were used to analyze these isolated CA-MRSA strains. In vitro antibiotic susceptibilities of those strains to 15 antibiotics were analyzed by using agar dilution method.
ResultsUp to 88.6% patients were late-onset infection and septicemia (24, 68.5%) was the most common infection among the 35 cases. A total of 16 patients (45.7%) suffered from complications. Caesarean section and premature birth were risk factors for invasive CA-MRSA infection. ST59-MRSA-SCCmecⅣa-t437 (14, 40%) was the most predominant CA-MRSA clone, followed by ST59-MRSA-SCCmecⅤ-t437 (13, 37.1%). The incidence of severe complications caused by ST59-MRSA-SCCmecⅤ-t437 was higher than that caused by ST59-MRSA-SCCmecⅣa-t437 (P<0.05). Up to 85.7% of the isolated CA-MRSA strains were multidrug-resistant strains.
ConclusionThis study shows that neonatal invasive CA-MRSA infections mainly result in septicemia and are often accompanied by complications and involve multiple organs. Multidrug-resistant CA-MRSA strains are prevalent in neonates. ST59-MRSA-SCCmecⅣa-t437 is the predominant clone causing neonatal invasive CA-MRSA infection.
Key words:
CA-MRSA; Neonate; Invasive infection
Contributor Information
Geng Wenjing
Neonatal Care Center, Beijing Children′s Hospital, Capital Medical University, Beijing 100045, China
Dong Fang
Department of Bacteriological Laboratory, Beijing Children′s Hospital, Capital Medical University, Beijing 100045, China
Weng Jingwen
Neonatal Care Center, Beijing Children′s Hospital, Capital Medical University, Beijing 100045, China
Dong Shixiao
Neonatal Care Center, Beijing Children′s Hospital, Capital Medical University, Beijing 100045, China
Jin Fei
Neonatal Care Center, Beijing Children′s Hospital, Capital Medical University, Beijing 100045, China
Shen Xuzhuang
Key Laboratory of Major Diseases in Children, Ministry of Education, National Key Discipline of Pediatrics, Beijing Institute of Pediatrics, Beijing Children′s Hospital, Capital Medical University, Beijing 100045, China
Qi Yujie
Neonatal Care Center, Beijing Children′s Hospital, Capital Medical University, Beijing 100045, China
