Research on Bladder Cancer
Clinical observation of radical transurethral photoselective vaporization of bladder tumours combined with chemotherapy in treating muscle invasive bladder cancer
Zhaoyi Li, Ruipeng Hou, Jian Li
Published 2015-07-15
Cite as Chin J Urol, 2015, 36(7): 487-489. DOI: 10.3760/cma.j.issn.1000-6702.2015.07.004
Abstract
ObjectiveTo explore the safety and clinical efficacy of radical transurethral photoselective vaporization of bladder tumours (RPVBT) combined with chemotherapy in the treatment of muscle invasive bladder cancer.
MethodsCollected during Sept. 2010 to Sept. 2012, a total of 34 patients with muscle invasive bladder cancer who refuse or older, merge the heavier medical disease, difficult to tolerate radical cystectomy.Using RPVBT, vaporization resection to the bladder wall fat layer, postoperatively systemic chemotherapy of gemcitabine combined cisplatin and bladder perfusion chemotherapy of pharmorubicin. The operation time、the first recurrent time and recurrent rate, and the survival rate were measured.
ResultsOperation are completed smoothly, operating time is 30.5–69.0 min and average 49.2 min, intraoperative rinses quantity is 5.9–10.7 L and average 8.3 L. Intraoperative no obvious bleeding, intraoperative no serioue complications, postoperative pathological diagnosis is invasive epithelial cell carcinoma of the urinary tract, pathology classification: low level 15cases, the high level 19 cases. Follow–up of 12 to 36 months, an average of 21 months, 9 cases of recurrence, 2 cases underwent radical cystectomy, 7 cases again RPVBT, the first tumor recurrence time 3–20 months, 11 months and the median time to relapse recurrence rate 26.5% (9/34), 3 cases of relapses diedof bladder cancer metastasis, 31 cases of survival.
ConclusionTreatment of RPVBT combination chemotherapy in patients with locally invasive bladder cancer, small trauma, less bleeding, high safety, have certain curative effect, It could be a effective treatment strategy for patients of high–risk elderly or unwilling to accept Radadical cystectomy.
Key words:
Muscleinvasive bladder cancer; Radical; Photoselective vaporization
Contributor Information
Zhaoyi Li
Department of Urology, The Union Medical Center of Tianjin, Tianjin 300121, China
Ruipeng Hou
Jian Li