Clinical Original Article
Comparative study of freehand and template-guided transperineal prostate biopsy in the detection rate of prostate cancer
Hengzhi Lin, Husheng Li, Biming He, Zhenkai Shi, Shuxiong Zeng, Guanyu Ren, Xia Sheng, Xu Gao, Chuanliang Xu, Yinghao Sun, Haifeng Wang
Published 2019-08-15
Cite as Chin J Urol, 2019, 40(8): 596-600. DOI: 10.3760/cma.j.issn.1000-6702.2019.08.008
Abstract
ObjectiveThis retrospective study compared the detection rates of prostate cancer between freehand transperineal biopsy(FTPB) and template-guided transperineal biopsy(TTPB) in the patients with PSA levels<20 ng/ml.
MethodsFrom April 2017 to April 2019, 768 patients with PSA levels <20 ng/ml were included into this study. Of these patients, 406 underwent FTPB procedures and 362 underwent TTPB procedures. There were no significant differences of median age [66.00(61.00, 70.00)vs. 66.00(61.00, 71.25)years], height [170.00(165.00, 172.00)vs. 170(165.00, 173.00)cm], weight [70.00(63.88, 75.00)vs. 70.00(63.75, 75.00)kg], BMI [24.22(22.22, 25.95)vs. 24.22(22.49, 25.82)kg/m2], PSA [8.75(6.49, 12.40)vs. 8.69(6.49, 11.96)ng/ml], fPSA [1.18(0.33, 2.15)vs. 1.15(0.76, 1.88)ng/ml], prostate volume [39.79(25.55, 53.94)vs. 39.88(24.46, 55.11)ml] between two groups. Patients’ biopsy results were recorded, the differences of prostate cancer detection rates between these two groups were analyzed, specifically including the cancer with Gleason score≥7 and the anterior zone cancer.
ResultsThe total prostate cancer detection rates were 33.7%(137/406) and 39.0%(141/362, P=0.134) in FTPB group and TTPB group respectively, and the detection rates of cancer with Gleason score≥7 were 23.9%(97/406) and 32.0%(116/362, P=0.012) respectively. The detection rates of anterior zone prostate cancer were 15.5% (63/406) and 27.3% (99/362, P<0.001). Moreover, in the patients with PSA <10 ng/ml, the prostate cancer detection rates were 29.8%(74/248) and 36.2%(81/224, P=0.144) respectively, while the detection rates of cancer with Gleason score≥7 were 19.4%(48/248) and 29.9%(67/224, P=0.008) respectively.
ConclusionsThere was no significant difference in the total prostate cancer detection rates between 12-core TTPB group and 20-core FTPB group in the patients with PSA <20 ng/ml, but for the detection rate of cancer with Gleason score≥7, TTPB group was significantly higher than FTPB group, especially in the patients with PSA<10 ng/ml. In addition, for anterior zone prostate cancer, the detection rate of TTPB group was also higher than FTPB group.
Key words:
Prostatic neoplasms; Diagnosis; Freehand biopsy; Template-guided biopsy; Transperineal
Contributor Information
Hengzhi Lin
Department of Urology, Shanghai Changhai Hospital, Shanghai 200433, China
Husheng Li
Biming He
Zhenkai Shi
Shuxiong Zeng
Guanyu Ren
Xia Sheng
Xu Gao
Chuanliang Xu
Yinghao Sun
Haifeng Wang
