Review
Progress in detection and clinical application of circulating tumor cells in renal cell carcinoma
Du Xin, Hong Baoan, Zhao Qiang, Ji Yongpeng, Yang Yong, Zhang Ning
Published 2020-02-15
Cite as Chin J Urol, 2020,41(02): 153-156. DOI: 10.3760/cma.j.issn.1000-6702.2020.02.016
Abstract
Renal cell carcinoma is one of the common malignant tumors in genitourinary cancer. 20%-30% of patients have distant metastases. However, current biomarkers used for diagnosis, recurrence monitoring, and prognosis assessment are still uncertain. Circulating tumor cells (CTCs) are tumor cells that are detached from the primary tumor or metastases, and invade and presenting in peripheral blood vessels. Therefore, CTCs is regarded as a key step in the process of tumor metastasis. However, current studies on CTCs of renal cell carcinoma are facing with problems such as inconsistent detection methods and limited clinical applications. This article reviews the progress in the detection and clinical application of CTCs of renal cell carcinoma.
Key words:
Carcinoma, renal cell; Circulating tumor cells (CTCs); Biomarker
Contributor Information
Du Xin
Department of Urology, Peking University Cancer Hospital & lnstitme, Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing), Beijing 100142, China
Hong Baoan
Department of Urology, Peking University Cancer Hospital & lnstitme, Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing), Beijing 100142, China
Zhao Qiang
Department of Urology, Peking University Cancer Hospital & lnstitme, Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing), Beijing 100142, China
Ji Yongpeng
Department of Urology, Peking University Cancer Hospital & lnstitme, Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing), Beijing 100142, China
Yang Yong
Department of Urology, Peking University Cancer Hospital & lnstitme, Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing), Beijing 100142, China
Zhang Ning
Department of Urology, Peking University Cancer Hospital & lnstitme, Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing), Beijing 100142, China