Systematic Reviews/Meta-analysis
Relationship between N-nitrosodimethylamine and risk of digestive tract cancers: a Meta analysis based on cohort studies
Juan Cui, Xiaomin Guo, Heling Bao, Jibin Tan
Published 2016-05-10
Cite as Chin J Epidemiol, 2016, 37(5): 725-729. DOI: 10.3760/cma.j.issn.0254-6450.2016.05.029
Abstract
ObjectiveTo analyze the relationship between N-nitrosodimethylamine(NDMA)and the risk of digestive tract cancers.
MethodsThe papers about the relationship between NDMA and the risk of digestive tract cancers published from 1980 to 2012 were retrieved following databases: Chinese BioMedical Literature Database(CBM), the Chinese Journal Full-text Database(CNKI), Wanfang Database, PubMed and EBSCO. The fix and random effect model was used and statistical analyses were conducted by using RevMan 5.1 software.
ResultsThirteen papers were found, in which 7 about digestive tract cancers were used in this Meta analysis. The NDMA had significant positive effect on the incidence of digestive tract cancers(RR=1.12, 95% CI: 1.03-1.21). The relationship between NDMA and esophageal cancer was not significant(RR=1.18, 95%CI: 0.98-1.41)but NDMA could increase the risk of gastric cancer(RR=1.08, 95% CI: 1.00-1.18). For the subtypes of esophageal and gastric cancer, NDMA had positive relationship with esophageal squamous cell carcinoma(RR=1.72, 95% CI: 1.01-2.96), but had no significant relationship with esophageal adenocarcinoma, cardiac carcinoma and gastric adenocarcinoma.
ConclusionThe population-based cohort studies have showed that the NDMA could significantly increase the risk of digestive tract cancers, but the effects differed with subtypes of esophageal and gastric cancer. However, it is necessary to collect more evidence due to the limited studies and obvious differences in the study design, sampling and exposure measurement of these cohort studies.
Key words:
N-nitrosodimethylamine; Esophageal cancer; Gastric cancer; Cohort; Meta analysis
Contributor Information
Juan Cui
National Center for Chronic and Non-communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100050, China
Xiaomin Guo
Chinese Center for Disease Control and Prevention, Beijing 102206, China
Heling Bao
National Center for Chronic and Non-communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100050, China
Jibin Tan
Chinese Center for Disease Control and Prevention, Beijing 102206, China
