Laboratory Research
HIV gene subtypes of newly reported HIV/AIDS cases in Dehong Dai and Jingpo autonomous prefecture of Yunnan province, 2016
Xing Duan, Keran Wang, Jibao Wang, Runhua Ye, Yikui Wang, Jin Yang, Tao Yang, Sujuan Zhou, Yuecheng Yang, Shitang Yao, Song Duan, Na He
Published 2018-05-10
Cite as Chin J Epidemiol, 2018, 39(5): 678-681. DOI: 10.3760/cma.j.issn.0254-6450.2018.05.027
Abstract
ObjectiveTo explore distribution of HIV gene subtypes among newly reported HIV/AIDS cases from China and Myanmar in Dehong Dai and Jingpo prefecture of Yunnan province in 2016.
MethodsWe conducted DNA extractions from newly reported HIV/AIDS cases in 2016. The gag, env and pol genes were amplified by using reverse transcription-PCR (RT-PCR) and sequenced to identify HIV subtypes.
ResultsA total of 1 112 newly diagnosed HIV cases were reported in Dehong in 2016, and the HIV subtypes were identified for 860 cases. Subtype C was predominant (33.6%), followed by unique recombinant forms (URFs) (28.4%), CRF01_AE (18.6%) and so on. URFs include four recombination, among which the recombination of CRF01_AE and C subtype were predominant. The HIV subtype distribution was associated with nationality and transmission route in HIV/AIDS cases from Myanmar.
ConclusionsThe gene subtypes of C, URFs and CRF01_AE were mainly distributed; distribution of URFs remained complex and diverse among newly reported HIV/AIDS cases in Dehong in 2016.
Key words:
HIV; HIV/AIDS cases; Gene subtypes
Contributor Information
Xing Duan
Dehong Dai and Jingpo Autonomous Prefectural Center for Disease Control and Prevention, Mangshi 678400, China
Department of Epidemiology, School of Public Health, Key Laboratory for Public Health Safety of Ministry of Education, Fudan University, Shanghai 200032, China
Keran Wang
Dehong Dai and Jingpo Autonomous Prefectural Center for Disease Control and Prevention, Mangshi 678400, China
Jibao Wang
Department of Epidemiology, School of Public Health, Key Laboratory for Public Health Safety of Ministry of Education, Fudan University, Shanghai 200032, China
Runhua Ye
Dehong Dai and Jingpo Autonomous Prefectural Center for Disease Control and Prevention, Mangshi 678400, China
Yikui Wang
Dehong Dai and Jingpo Autonomous Prefectural Center for Disease Control and Prevention, Mangshi 678400, China
Jin Yang
Dehong Dai and Jingpo Autonomous Prefectural Center for Disease Control and Prevention, Mangshi 678400, China
Tao Yang
Dehong Dai and Jingpo Autonomous Prefectural Center for Disease Control and Prevention, Mangshi 678400, China
Sujuan Zhou
Department of Epidemiology, School of Public Health, Key Laboratory for Public Health Safety of Ministry of Education, Fudan University, Shanghai 200032, China
Yuecheng Yang
Dehong Dai and Jingpo Autonomous Prefectural Center for Disease Control and Prevention, Mangshi 678400, China
Shitang Yao
Dehong Dai and Jingpo Autonomous Prefectural Center for Disease Control and Prevention, Mangshi 678400, China
Song Duan
Dehong Dai and Jingpo Autonomous Prefectural Center for Disease Control and Prevention, Mangshi 678400, China
Na He
Department of Epidemiology, School of Public Health, Key Laboratory for Public Health Safety of Ministry of Education, Fudan University, Shanghai 200032, China
