Field Epidemiology
Influence on physical development of children aged 18 months from HIV-positive mothers for prevention mother to child transmission of HIV
Ge Xianmin, Yang Wenmin, Shen Zhiyong, Chen Huanhuan, Li Bin, Meng Qin, Luo Liuhong, Lu Huaxiang, Zhu Jinhui, Lan Guanghua, Zhu Qiuying, Wu Xiuling, Huang Guanghua, Fu Botao, Huang Zhuoxin, Li Jiawei, Chen Jinmei, Chen Zhenqiang, Yang Jin, Yan Yu
Published 2020-03-10
Cite as Chin J Epidemiol, 2020,41(03): 354-357. DOI: 10.3760/cma.j.issn.0254-6450.2020.03.014
Abstract
ObjectiveTo explore influence on physical development of children aged 18 months from HIV-positive mothers for prevention mother to child transmission of HIV (PMTCT) in Guangxi Zhuang autonomous region, and provide evidence for the improvement PMTCT program.
MethodsThis retrospective case control study was conducted in 554 HIV negative infants aged 18 months whose HIV positive mothers had received PMTCT services reported through PMTCT system database from January 1, 2010 to December 31, 2017 and 1 109 healthy infants born in 2017, whose mothers were healthy, in Lingshan, Luzhai, and Hengxian counties, ranking top three counties with high HIV infection prevalence, in Guangxi. PMTCT data and physical development data such as height, weight and head circumference of children aged 18 months were collected. The physical dysplasia in the infants was defined as at least one of the three main indicators of height, weight and head circumference below the normal range.
ResultsThe number of HIV-positive mother and their infants in the case group were 667 and 554 respectively, and the PMTCT rates were 91.15% (608/667) and 96.57% (535/554) respectively. HIV positive rate, mortality rate and mother to child transmission rate of the infants aged 18 months were 1.44% (8/554), 3.07% (17/554) and 1.91% (8/418) respectively, and the physical examination results of the infants aged 18 months showed that the physical dysplasia rate was 30.51% (169/554). Among the 1 109 infants in the control group, the physical dysplasia rate was 9.83% (109/1 109). The difference between the case group and the control group was significant (P<0.01).
ConclusionThe PMTCT rates of HIV positive mother and their children were more than 90.00%, respectively. However, poor physical development rate of infants aged 18 months were more than 30.00%. The possible influence of PMTCT on physical development of the infants aged 18 months of HIV positive mother’s needs to be further studied.
Key words:
HIV/AIDS; Preventing mother to child transmission; Antiretroviral treatment; Physical development
Contributor Information
Ge Xianmin
Guangxi Zhuang Autonomous Region Center for Disease Control and Prevention, Nanning 530028, China
Yang Wenmin
Guangxi Zhuang Autonomous Region Center for Disease Control and Prevention, Nanning 530028, China
Shen Zhiyong
Guangxi Zhuang Autonomous Region Center for Disease Control and Prevention, Nanning 530028, China
Chen Huanhuan
Guangxi Zhuang Autonomous Region Center for Disease Control and Prevention, Nanning 530028, China
Li Bin
Guangxi Zhuang Autonomous Region Center for Disease Control and Prevention, Nanning 530028, China
Meng Qin
Guangxi Zhuang Autonomous Region Center for Disease Control and Prevention, Nanning 530028, China
Luo Liuhong
Guangxi Zhuang Autonomous Region Center for Disease Control and Prevention, Nanning 530028, China
Lu Huaxiang
Guangxi Zhuang Autonomous Region Center for Disease Control and Prevention, Nanning 530028, China
Zhu Jinhui
Guangxi Zhuang Autonomous Region Center for Disease Control and Prevention, Nanning 530028, China
Lan Guanghua
Guangxi Zhuang Autonomous Region Center for Disease Control and Prevention, Nanning 530028, China
Zhu Qiuying
Guangxi Zhuang Autonomous Region Center for Disease Control and Prevention, Nanning 530028, China
Wu Xiuling
Guangxi Zhuang Autonomous Region Center for Disease Control and Prevention, Nanning 530028, China
Huang Guanghua
Lingshan County Center for Disease Control and Prevention, Lingshan 535400, China
Fu Botao
Luzhai County Center for Disease Control and Prevention, Luzhai 545600, China
Huang Zhuoxin
Hengxian County Center for Disease Control and Prevention, Hengxian 530300, China
Li Jiawei
Lingshan County Maternal and Child Health Care Center, Lingshan 535400, China
Chen Jinmei
Lingshan County Center for Disease Control and Prevention, Lingshan 535400, China
Chen Zhenqiang
Luzhai County Center for Disease Control and Prevention, Luzhai 545600, China
Yang Jin
Hengxian County Center for Disease Control and Prevention, Hengxian 530300, China
Yan Yu
Lingshan County Maternal and Child Health Care Center, Lingshan 535400, China
