Cross-sectional analysis on drug resistance profile of acquired immune deficiency syndrome patients receiving a long-term antiretroviral treatment in Henan
CUI Wei-guo, LIU Jia, XUE Xiu-juan, SUN Guo-qing, TIAN Sui-an, LIU Chun-hua, WANG Zhe
Published 2012-05-30
Cite as Chin J Exp Clin Virol, 2012,26(03): 168-171. DOI: 10.3760/cma.j.issn.1003-9279.2012.03.003
Abstract
Objective To elucidate the condition of drug resistance among acquired immune deficiency syndrome (AIDS) patients with a long-term antiretroviral treatment in Henan province,provide some useful data for such patients to continue effective treatment.Method Patients beginning first-line antiretroviral treatment before and after 2004 were selected in two counties of Henan.CD4+ T cells,virus load and genotypic resistance(In-house) were tested.Results A total of 164 patients were selected in two counties,with a median (interquartile range,IQR) CD4+T cells 398.00 (242.00-489.50 )cells/μl,32.32% of the patients had a virus load lower than the lowest detected level.Ninety-five patients had a virus load more than 1000 copies/ml,77 of them completed the drug resistance test,drug resistance mutations occurred in 68.83%,the NNRTIs and NRTIs mutations were found in 64.94% and 55.84% of them,respectively,no PIs mutations were detected. K103N/S (44.16%) was the most frequent NNRTIs mutations that have occurred,followed by G190A/S (19.48%) and Y181C/V (14.29% ).Thymidine analogue mutations (TAMs) was the most common NRTIs mutations that have occurred,≥1TAM accounted for 46.75%,TAM-1/TAM-2 accounted for 24.68%.M184V/I was also the NRTIs mutations.Among the 77 patients,the proportion of patients who had resistance to the NRTIs:ddI,3TC,AZT,D4T and TDF was 50.65%,33.77%,48.05%,50.65% and 46.75% respectively,the proportion of patients who had resistance to the NNRTIs:EFV,NVP and DLV was 64.94%,64.94% and 62.34%,respectively.Conclusion The situation of drug resistance among AIDS patients treated with a long-term antiretroviral treatment in Henan province was serious,more attention and timely treatment adjustment are needed to such patients with AIDS.
Key words:
Acguired immunodeficiency syndrome; Drug resistence; Antiviral agents; Crosssectional studies
Contributor Information
CUI Wei-guo
Henan Provincial Center for Disease Control and Prevention, Zhengzhou 450016, China
LIU Jia
Henan Provincial Center for Disease Control and Prevention, Zhengzhou 450016, China
XUE Xiu-juan
Henan Provincial Center for Disease Control and Prevention, Zhengzhou 450016, China
SUN Guo-qing
Henan Provincial Center for Disease Control and Prevention, Zhengzhou 450016, China
TIAN Sui-an
Henan Provincial Center for Disease Control and Prevention, Zhengzhou 450016, China
LIU Chun-hua
Henan Provincial Center for Disease Control and Prevention, Zhengzhou 450016, China
WANG Zhe
Henan Provincial Center for Disease Control and Prevention, Zhengzhou 450016, China