Diagnosis and Treatment of Viral Diseases
Infection status of human papillomavirus and its genotype distribution among 24 450 women in Meizhou, Guangdong province
Pingsen Zhao, Runqing Jia, Lifang Lin, Luxian Su, Zhixiong Zhong, Yi Zeng
Published 2016-06-30
Cite as Chinese J Exp Clin Virol, 2016, 30(3): 311-314. DOI: 10.3760/cma.j.issn.1003-9279.2016.03.014
Abstract
ObjectiveTo investigate the situation of human papillomavirus (HPV) infection and the distribution of HPV genotypes among women attending hospital in Meizhou, Guangdong province.
MethodsFlow-through hybridization and gene chip technique was used to detect HPV in cervical exfoliated cell specimens collected from 24 450 women for HPV screening in Department of Gynecology, Meizhou People′s Hospital, Meizhou Hospital Affiliated to Sun Yat-sen University, and then the situation of HPV infection and distribution of HPV genotypes were analyzed.
ResultsAmong 24 450 female exfoliated cell specimens, 3 922 were found to be positive for HPV infection, with the total infection rate of 16.04%. Among 3 922 samples, the top three high-risk subtypes of HPV were HPV-16 (30.37%), HPV-52 (17.77%) and HPV-58 (15.53%), the majority of low-risk HPV was HPV-CP8304 (5.61%). The positivity of various HPV types peaked among 30-50 years old. The differences of the HPV positive rates in different age groups was statistical significance (P<0.001).
ConclusionsThe majority of women attending hospital detected with HPV-16 in Meizhou and the positivity of various HPV types peaked among women aged 30-50 years. Genotyping of HPV was meaningful for preventing and treating cervical cancer.
Key words:
Human papillomavirus; Flow-through hybridization; Genotyping
Contributor Information
Pingsen Zhao
Meizhou People′s Hospital, Meizhou Hospital Affiliated to Sun Yat-sen University, Meizhou 514031, China
Runqing Jia
College of Life Science and Bioengineering, Beijing University of Technology, Beijing 100124, China
Lifang Lin
Meizhou People′s Hospital, Meizhou Hospital Affiliated to Sun Yat-sen University, Meizhou 514031, China
Luxian Su
Meizhou People′s Hospital, Meizhou Hospital Affiliated to Sun Yat-sen University, Meizhou 514031, China
Zhixiong Zhong
Meizhou People′s Hospital, Meizhou Hospital Affiliated to Sun Yat-sen University, Meizhou 514031, China
Yi Zeng
College of Life Science and Bioengineering, Beijing University of Technology, Beijing 100124, China
