Value of local progression-free survival for evaluating local outcome of peripheral lung cancer treated by cyberknife
ZHUANG Hong-qing, YUAN Zhi-yong, WANG Ping, SONG Yong-chung, DONG Yang, LI Feng-tong, WANG Jing-sheng
Published 2013-03-15
Cite as Chin J Radiat Oncol, 2013,22(02): 115-117. DOI: 10.3760/cma.j.issn.1004-4221.2013.02.008
Abstract
Objective To investigate the value of local progression-free survival (LPFS) for evaluating the local long-term outcome of peripheral lung cancer treated by cyberknife.Methods Retrospective analysis was performed on the clinical records of 81 cyberknife-treated lung cancer patients (90 foci),including 43 primary lung cancer patients (43 foci) and 38 metastatic lung cancer patients (47 foci).Of all the patients,58(63 foci) were treated at a dose of 60 Gy/3 fractions (20 Gy/fraction),and 23 (27 foci) at a dose of 54 Gy/3 fractions (18 Gy/fraction).The short-term treatment outcome and LPFS were used as the indices for observation;a logistic regression was used for analyzing the predictive value of LPFS for local long-term treatment outcome.Results After the evaluation of short-term treatment outcome,63% of all the foci needed further evaluation.As the follow-up lasted,the number of foci which needed further evaluation decreased,most rapidly during 0.5-2 years after treatment.Re-evaluation results had predictive value for the treatment outcome in the subsequent follow-up,but the predictive value declined as the follow-up lasted.Conclusions LPFS is a recommendable index for evaluating the local outcome of primary or metastatic lung cancer treated by cyberknife,and it also has predicative value for local long-term treatment outcome.
Key words:
Lung neoplasms/radiotherapy; Radiotherapy, Cyberknife; Local progression free survival; Treatment outcome evaluation
Contributor Information
ZHUANG Hong-qing
Department of Radiation Oncology, Cancer Hospital of Tianjin Medical university, Tianjin Lung Cancer Center, Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060,China
YUAN Zhi-yong
Department of Radiation Oncology, Cancer Hospital of Tianjin Medical university, Tianjin Lung Cancer Center, Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060,China
WANG Ping
Department of Radiation Oncology, Cancer Hospital of Tianjin Medical university, Tianjin Lung Cancer Center, Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060,China
SONG Yong-chung
Department of Radiation Oncology, Cancer Hospital of Tianjin Medical university, Tianjin Lung Cancer Center, Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060,China
DONG Yang
Department of Radiation Oncology, Cancer Hospital of Tianjin Medical university, Tianjin Lung Cancer Center, Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060,China
LI Feng-tong
Department of Radiation Oncology, Cancer Hospital of Tianjin Medical university, Tianjin Lung Cancer Center, Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060,China
WANG Jing-sheng
Department of Radiation Oncology, Cancer Hospital of Tianjin Medical university, Tianjin Lung Cancer Center, Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060,China