Head And Neck Tumor
Prognostic values of 18F-FDG PET/CT parameters in patients with nasopharyngeal carcinoma
Chengtao Wang, Bin Ouyang, Tian Zhang, Jun Dong, HU Kenneth S., Bixiu Wen
Published 2016-03-15
Cite as Chin J Radiat Oncol, 2016, 25(3): 207-211. DOI: 10.3760/cma.j.issn.1004-4221.2016.03.003
Abstract
ObjectiveAt present, nasopharyngeal carcinoma (NPC) is a head and neck cancer with special geographical distribution and biological behavior. Studies have shown that 18F-FDG PET/CT parameters have certain prognostic values in patients with NPC in high-incidence areas. The aim of this study is to investigate the prognostic values of 18F-FDG PET/CT parameters in patients with NPC in low-incidence areas.
MethodsThe clinical data of 83 NPC patients who were diagnosed and treated in Beth Israel Medical Center, Albert Einstein Medical College from January 2003 to December 2013 were analyzed retrospectively. Based on 18F-FDG PET/CT images, gross tumor volume (GTV) was delineated using the gradient method to obtain 18F-FDG PET/CT parameters: maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV), and total lesion glycolysis (TLG).
ResultsThe number of patients followed was 37 at 3-years time. For all patients, the 3-year failure-free survival, locoregional relapse-free survival, and metastasis-free survival rates were 74%, 88%, and 85%, respectively. The univariate analysis showed that SUVmax of the primary tumor (P=0.004) and TLG (P=0.014) were prognostic factors for 3-year locoregional relapse-free survival rate, and SUVmax of the primary tumor (P=0.024) and TLG (P=0.033) were prognostic factors for 3-year failure-free survival rate. The multivariate analysis showed that SUVmax of the primary tumor was the independent prognostic factor for 3-year failure-free survival rate. Conclusion SUVmax of the primary tumor before treatment is the independent prognostic factor for failure-free survival in patients with NPC.
Key words:
Tomography, positron emission; Maximum standardized uptake value; Total lesion glycolysis; Nasopharyngeal neoplasms/radiotherapy; Nasopharyngeal neoplasms/chemotherapy; Prognosis
Contributor Information
Chengtao Wang
Department of Radiation Oncology, First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China
Departments of Radiation Oncology, Mount Sinai Beth Israel Medical Center, New York, NY 10003, U.S.A.
Bin Ouyang
Department of Radiation Oncology, First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China
Tian Zhang
Department of Radiation Oncology, First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China
Jun Dong
Department of Radiation Oncology, First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China
HU Kenneth S.
Departments of Radiation Oncology, Mount Sinai Beth Israel Medical Center, New York, NY 10003, U.S.A.
Bixiu Wen
Department of Radiation Oncology, First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China