Abdominal Tumor
Clinical features and treatment outcome of inflammatory myofibroblastic tumor: a retrospective study of 58 patients
Jianghu Zhang, Li Gao, Junlin Yi, Lin Yang, Guozhen Xu, Jingwei Luo, Jianping Xiao, Kai Wang, Yuan Qu, Shiping Zhang, Xiaodong Huang
Published 2017-06-15
Cite as Chin J Radiat Oncol, 2017, 26(6): 646-649. DOI: 10.3760/cma.j.issn.1004-4221.2017.06.008
Abstract
ObjectiveTo evaluate the risk of locoregional recurrence (LRR) and the influencing factors for long-term survival in patients with inflammatory myofibroblastic tumor (IMT).
MethodsA retrospective analysis was performed for 58 IMT patients who completed initial therapy or initial adjuvant therapy in our hospital from January 2002 to January 2017 to evaluate their failure patterns and survival. The LRR and survival rates were compared between groups. The Kaplan-Meier method was used to calculate survival rates, and the log-rank test was used for survival difference analysis and univariate prognostic analysis.
ResultsThe median follow-up time was 34 months. Among the 58 patients, 50 underwent surgery alone, and 8 underwent surgery and adjuvant therapy. Seventeen patients experienced treatment failure, 16 patients developed LRR, 3 patients developed distant metastasis, including 2 patients with local failure, and 5 patients died of tumor recurrence or metastasis. The 5-year LRRFS was 75%, and the 5-year OS rate was 90%.The univariate analysis showed that resection margin and local staging were influencing factors for LRRFS (P=0.018, 0).
ConclusionsRadical resection combined with adjuvant therapy is the key to improving the treatment outcome of IMT.
Key words:
Inflammatory myofibroblastic neoplasms/surgery; Inflammatory myofibroblastic neoplasms/postoperative radiotherapy; Treatment outcome
Contributor Information
Jianghu Zhang
Department of Radiation Oncology, National Cancer Center/Cancer Hospital, Chinese Academy-of Medical Sciences, Peking Union Medical College, Beijing 100021, China
Li Gao
Junlin Yi
Lin Yang
Guozhen Xu
Jingwei Luo
Jianping Xiao
Kai Wang
Yuan Qu
Shiping Zhang
Xiaodong Huang