Thoracic Tumor
Radiological features of non-small-cell lung cancer with brain metastases in a single center: an implication for the HA-WBRT approach
Yimin Han, Weimin Chai, Cheng Xu, Lu Cao, Dan Ou, Gang Cai, Jiayi Chen
Published 2018-09-15
Cite as Chin J Radiat Oncol, 2018, 27(9): 798-804. DOI: 10.3760/cma.j.issn.1004-4221.2018.09.002
Abstract
ObjectiveWhole brain radiotherapy (WBRT) remains the primary treatment for patients with multiple brain metastases (BM). Hippocampal avoidance WBRT (HA-WBRT) offers the feasibility of less cognitive function impairment than conventional WBRT.WBRT yields better control rate of intracranial distant progression than stereotatic body radiotherapy (SBRT). This study aims to understand the distribution characteristics of BM within the cranial structures by analyzing imaging features and define the safe margin during HA-WBRT.
MethodsClinical data of patients diagnosed with BM by enhanced MRI in Ruijin Hospital from July 2011 to July 2016 were retrospectively analyzed. The distance between the intracranial lesion closest to the hippocampus and the hippocampus was measured.
ResultsA total of 146 patients (90 male and 56 female) with 630 BM lesions were reviewed. Sixty-four patients were diagnosed with non-small-cell lung cancer complicated with BM during the initial admission. In the other 82 patients, the average time from the initial diagnosis to the diagnosis of BM was (14.5±14.3) months. In total, 486(77.1%) BM lesions were situated beyond the tentorium. The average diameter of the largest intracranial lesion was (12.5±10.3) mm (95%CI: 10.8-14.2). All 630 BM lesions were distributed as follows: 138(21.9%) in the cerebellum, 182(28.9%) in the frontal lobe, 114(18.1%) in the temporal lobe, 78(12.4%) in the parietal lobe, 87(12.7%) in the occipital lobe, 28(4.4%) in the thalamus and 10(1.6%) in the brainstem. The frequency of hippocampal involvement was 3.4%(5 mm), 4.8%(10 mm) and 8.2%(20 mm). The univariate and multivariate logistic analyses indicated that with the risk of hippocampal involvement in patients aged> 60 years was significantly increased (OR=11.576 P=0.042).
ConclusionsThe probability of brain metastasis within 10 mm around the hippocampus is low. HA-WBRT can control the intracranial lesions and reduce cognitive impairment, which is a safe and feasible treatment method.
Key words:
Lung neoplasm/whole brain radiotherapy; Hippocampal avoidance; Brain metastasis; Hippocampal involvement
Contributor Information
Yimin Han
Department of Radiation Oncology, Ruijin Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai 200025, China
Weimin Chai
Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai 200025, China
Cheng Xu
Department of Radiation Oncology, Ruijin Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai 200025, China
Lu Cao
Department of Radiation Oncology, Ruijin Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai 200025, China
Dan Ou
Department of Radiation Oncology, Ruijin Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai 200025, China
Gang Cai
Department of Radiation Oncology, Ruijin Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai 200025, China
Jiayi Chen
Department of Radiation Oncology, Ruijin Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai 200025, China
