Thoracic Tumor
Comparison of survival between neoadjuvant chemoradiotherapy and neoadjuvant chemotherapy followed by surgery for esophageal squamous cell carcinoma
Fan Chengcheng, Feng Zhuo, Ge Hong, Ye Ke, Wang Hao, Zheng Xiaoli, Zhang Yougai, Song Shuai, Ni Peizan, Zhang Ruiyun, Luo Hui
Published 2019-12-15
Cite as Chin J Radiat Oncol, 2019,28(12): 890-895. DOI: 10.3760/cma.j.issn.1004-4221.2019.12.003
Abstract
ObjectiveTo compare the effect of neoadjuvant chemoradiotherapy (NCRT) and neoadjuvant chemotherapy (NCT) on the survival of patients with esophageal cancer.
MethodsClinical data of 275 cases of thoracic esophageal squamous cell carcinoma treated with neoadjuvant therapy combined with surgery from December 2011 to December 2015 were analyzed retrospectively. The data of treatment and follow-up were complete and analyzable. There were 70 cases in the NCRT group and 205 cases in the NCT group. The survival rate was calculated by Kaplan-Meier method and statistically compared by log-rank test, and multivariate analysis was performed by Cox regression model.
ResultsThe median follow-up time was 32(3-84) months. The median survival time and recurrence-free survival time was 42(3-84) months and 30(3-84) months, respectively. The overall 3-and 5-year survival rates were 56.8% and 45.9%, respectively, and the 3-and 5-year recurrence-free survival rates were 45.1% and 38.9%, respectively. The median survival time in the NCRT and NCT groups was 46(7-84) and 40(4-74) months, and the median recurrence-free survival time was 31(3-84) and 28(3-69) months, respectively. The 3-and 5-year overall survival of the two groups were 59.1%, 47.1% and 56.3%, 47.5%(P=0.515), and the 3-and 5-year recurrence-free survival were 44.5%, 40.1% and 47%, 39%, respectively. There was no significant difference in the survival between two neoadjuvant therapy modes (P=0.554). Multivariate analysis showed that postoperative pathological TNM staging was an independent factor affecting the prognosis of patients with esophageal cancer (P=0.001).
ConclusionsThe survival results of NCRT are similar to those of NCT. Postoperative pathological staging is an independent survival factor.
Key words:
Esophageal neoplasm/neoadjuvant radiotherapy; Esophageal neoplasm/neoadjuvant chemotherapy; Prognosis
Contributor Information
Fan Chengcheng
Department of Radiation Oncology, Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou 450008, China
Feng Zhuo
Ge Hong
Ye Ke
Wang Hao
Zheng Xiaoli
Zhang Yougai
Song Shuai
Ni Peizan
Zhang Ruiyun
Luo Hui
