Original Article
A magnetoencephalography study on auditory sensory gating in schizophrenia
Wang Ying, Feng Yigang, Jia Yanbin, Xie Yanping, Zhong Shuming, Wang Wensheng, Guan Yufang, Zhu Dan, Huang Li
Published 2014-06-05
Cite as Chin J Psychiatry, 2014,47(03): 151-157. DOI: 10.3760/cma.j.issn.1006-7884.2014.03.006
Abstract
ObjectiveTo explore the neural mechanism of auditory sensory gating function in schizophrenia using magnetoencephalography (MEG).
MethodsWhole-head MEG data were acquired during the standard paired-click paradigm in 20 schizophrenia patients and 20 healthy controls. The M50, M100 and M200 responses were investigated, and dipole source localization was performed. Sensory gating ratios were determined by measuring the strength of the M50, M100 and M200 response to the second click divided by that of the first click (S2/S1).
ResultsIn every subject, M50, M100 and M200 dipolar sources localized to the left and right posterior portion of superior temporal gyrus (STG). The bilateral M50 gating ratios and M50 S2 source strengths were significantly higher in the schizophrenia group compared to the control group （patients, M50 gating left (0.87±0.39), right (0.82±0.34); M50 S2 strengths left （15.47±7.81） nAm, right （14.26±4.54） nAm; controls, M50 gating left (0.53±0.28), right (0.53±0.34); M50 S2 strengths left （10.38±5.55） nAm, right （9.76±5.77） nAm, P<0.05）.The bilateral M100 gating ratios and M100 S2 source strengths were significantly higher in the schizophrenia group compared to the control group （patients, M100 gating left (0.98±0.40), right (0.86±0.42); M100 S2 strengths left （28.17±18.96） nAm, right （33.36±16.06） nAm; controls, M100 gating left (0.55±0.22), right (0.52±0.16); M100 S2 strengths left （15.93±8.25） nAm, right （16.07±5.98） nAm, P<0.05）.The left hemispheric M200 gating ratio was significantly higher in the schizophrenia group compared to the control group (patients 0.95±0.51; controls 0.51±0.22, P<0.01). The left hemispheric S1- M50 latency was significantly shorter in the schizophrenia group compared to the control group （patients, (53.44±13.67) ms; controls, (62.46±9.89) ms, P<0.05）. No significant correlations were found between PANSS scores and bilateral M50, M100, M200（r=-0.351, r=0.206, r=-0.287, r=0.361, r=-0.265, r=-0.093， all P>0.05）.
ConclusionsSchizophrenia patients have auditory gating deficits at both pre-attentive and early attentive levels, which might be related to STG structural/functional abnormality.
Key words:
Schizophrenia; Magnetoencephalography; Superior temporal gyrus; Auditory evoked fields; Sensory gating
Contributor Information
Wang Ying
Clinical Experimental Center, First Affiliated Hospital of Jinan University, Guangzhou 510630, China
Feng Yigang
Jia Yanbin
Xie Yanping
Zhong Shuming
Wang Wensheng
Guan Yufang
Zhu Dan
Huang Li
