Obsessive-compulsive and Related Disorders
A preliminary observation of resting-state functional connectivity of bilateral amygdale in drug-naive patients with obsessive-compulsive disorder
Chen Yunhui, Li Ping, Lyu Dan, Jia Cuicui, Zhang Guangfeng, Wang Yuhua, Sun Zhenghai, Wang Wei, Wang Yefu, Guo Yu
Published 2020-04-05
Cite as Chin J Psychiatry, 2020,53(02): 122-128. DOI: 10.3760/cma.j.cn113661-20190707-00219
Abstract
ObjectiveTo explore the pattern of resting-state functional connectivity of bilateral amygdale in drug-naive obsessive-compulsive disorder (OCD).
MethodsForty patients with OCD matched the criteria of International Classification of Diseases-10 and 38 gender-, age-, education-matched healthy subjects participated in the resting-state brain functional magnetic resonance imaging scan. The Yale-Brown Obsessive-Compulsive Scale, 17-Hamilton Depression Rating Scale and Hamilton Anxiety Rating Scale (HAMA) were used to assess the clinical symptoms of obsession, compulsion, depression and anxiety. Based on the Data Processing & Analysis for (Resting-State) Brain Imaging software, a voxel-based functional connectivity approach was used to explore the pattern of resting-state functional connectivity of bilateral amygdala in OCD; Pearson correlation analyses was used to analyze the relationship between the abnormal functional connectivity values and clinical symptoms in OCD.
ResultsCompared with the controls, patients with OCD showed decreased functional connectivity values between left amygdale and right dorsal anterior insula (0.16±0.13 vs. 0.27±0.13, t=-2.75, P<0.05, Gaussian random field (GRF) corrected, two-tailed), and between left amygdale and left ventral anterior cingulate cortex (0.09±0.12 vs. 0.19±0.13, t=-3.40, P<0.05, GRF corrected, two-tailed). The functional connectivity between left amygdale and right dorsal anterior insula was positively correlated with HAMA total score (r=0.377, P=0.016, uncorrected).
ConclusionsAt resting-state, the functional connectivities of the emotional regulation network decreased in drug-naive patients with OCD. Decreased functional connection between left amygdale and right dorsal anterior insula may be associated with anxiety symptoms in patients with OCD.
Key words:
Obsessive-compulsive disorder; Amygdala; Magnetic resonance imaging; Emotional regulation network
Contributor Information
Chen Yunhui
Department of Clinical Psychology, School of Psychiatry, Qiqihar Medical University, Qiqihar 161006, China
Li Ping
Institute of Mental Health, School of Psychiatry, Qiqihar Medical University, Qiqihar 161006, China
Lyu Dan
Institute of Mental Health, School of Psychiatry, Qiqihar Medical University, Qiqihar 161006, China
Jia Cuicui
Institute of Mental Health, School of Psychiatry, Qiqihar Medical University, Qiqihar 161006, China
Zhang Guangfeng
Department of MRI, the Third Affiliated Hospital of Qiqihar Medical University, Qiqihar 161000, China
Wang Yuhua
Department of Clinical Psychology, School of Psychiatry, Qiqihar Medical University, Qiqihar 161006, China
Sun Zhenghai
Department of Psychological Outpatient, the Fourth Affiliated Hospital of Qiqihar Medical University, Qiqihar 161006, China
Wang Wei
Department of Library, Qiqihar Medical University, Qiqihar 161006, China
Wang Yefu
Institute of Mental Health, School of Psychiatry, Qiqihar Medical University, Qiqihar 161006, China
Guo Yu
Department of Clinical Psychotherapy, Qiqihar Mental Health Center, Qiqihar 161000, China
