Effect of type 2 diabeteson middle cerebral artery occlusion-induced focal cerebral ischemia
JIA Ying, SONG Yue-jia, ZAN Li-kun, TENG Guo-xin, LIU Na, ZHOU Min, SUN Yu-lan, QI Ji-ping
Published 2011-04-08
Cite as Chin J Neurol, 2011,44(04): 238-241. DOI: 10.3760/cma.j.issn.1006-7876.2011.04.004
Abstract
:Objective To study thefunction of vascular endothelial growth factor (VEGF) in type 2 diabetes model rats andits effect on focal cerebral ischemia induced by middle cerebral artery occlusion in theserats. Methods Focal cerebral ischemia was induced by middle cerebral artery occlusion for6 hours in type 2 diabetes rats and normal control rats.Blood vessels morphology wasexamined by ink perfusion,infarct size was measured by TTC and expression of VEGF and CD34were evaluated by immunohistochemistry staining. Results Ink perfusion revealed increasednumber of small vessels in type 2 diabetes rats. Infarct size was significantly smaller intype 2 diabetes rats ( ( 80. 07 ± 11.21 ) mm3 ) than that in normal controls ((98. 91 ±14. 86) mm3,t = 2.48,P = 0. 0326). There were more hemorrhage lesions in the ischemichemisphere in type 2 diabetes rats when comparing with the controls. VEGF and CD34 showedsignificantly higher expression in type 2 diabetes rats than in normal controls.Conclusions High expression of VEGF and CD34 are found in type 2 diabetes rats aftermiddle cerebral artery occlusion. There is cerebrolvascular remodeling in diabetes rats.While this diabetes-induced remodeling appears to prevent infarct expansion,the changesalso increase the risk of hemorrhagic transformation. The latter may result in poorprognosis.
Contributor Information
JIA Ying
Department of Pathology,the First Clinical Hospital,Harbin MedicalUniversity,Harbin 150001,China
SONG Yue-jia
Department of Pathology,the First Clinical Hospital,Harbin MedicalUniversity,Harbin 150001,China
ZAN Li-kun
Department of Pathology,the First Clinical Hospital,Harbin MedicalUniversity,Harbin 150001,China
TENG Guo-xin
Department of Pathology,the First Clinical Hospital,Harbin MedicalUniversity,Harbin 150001,China
LIU Na
Department of Pathology,the First Clinical Hospital,Harbin MedicalUniversity,Harbin 150001,China
ZHOU Min
Department of Pathology,the First Clinical Hospital,Harbin MedicalUniversity,Harbin 150001,China
SUN Yu-lan
Department of Pathology,the First Clinical Hospital,Harbin MedicalUniversity,Harbin 150001,China
QI Ji-ping
Department of Pathology,the First Clinical Hospital,Harbin MedicalUniversity,Harbin 150001,China