Review
Advances of muscular atrophy and denervation after stroke
Jiang Zimu, Liang Jiahui, Li Jianle, Chen Chunyong, Li Pingping, Wei Jiating, Zeng Jinsheng
Published 2020-12-08
Cite as Chin J Neurol, 2020, 53(12): 1063-1067. DOI: 10.3760/cma.j.cn113694-20200325-00207
Abstract
It was generally believed that muscular atrophy of paralyzed limbs after stroke was due to disuse. However, recent studies have found that secondary lesions of motor neurons in the contralateral anterior horn of the spinal cord and the decrease of motor units lead to denervation, which plays an essential role in muscular atrophy and muscle fiber type transition. This article reviews the phenomenon and mechanism of muscular atrophy and denervation of paralyzed limbs after stroke, to provide a reference for clinical evaluation and experimental research.
Key words:
Stroke; Muscular atrophy; Denervation; Secondary lesion
Contributor Information
Jiang Zimu
Department of Neurology, the First Affiliated Hospital, Sun Yat-sen University, Guangdong Provincial Key Laboratory for Diagnosis and Treatment of Major Neurological Diseases, Guangzhou 510080, China
Liang Jiahui
Department of Neurology, the First Affiliated Hospital, Sun Yat-sen University, Guangdong Provincial Key Laboratory for Diagnosis and Treatment of Major Neurological Diseases, Guangzhou 510080, China
Li Jianle
Department of Neurology, the First Affiliated Hospital, Sun Yat-sen University, Guangdong Provincial Key Laboratory for Diagnosis and Treatment of Major Neurological Diseases, Guangzhou 510080, China
Chen Chunyong
Department of Neurology, the First Affiliated Hospital, Sun Yat-sen University, Guangdong Provincial Key Laboratory for Diagnosis and Treatment of Major Neurological Diseases, Guangzhou 510080, China
Li Pingping
Department of Neurology, the First Affiliated Hospital, Sun Yat-sen University, Guangdong Provincial Key Laboratory for Diagnosis and Treatment of Major Neurological Diseases, Guangzhou 510080, China
Wei Jiating
Department of Neurology, the First Affiliated Hospital, Sun Yat-sen University, Guangdong Provincial Key Laboratory for Diagnosis and Treatment of Major Neurological Diseases, Guangzhou 510080, China
Zeng Jinsheng
Department of Neurology, the First Affiliated Hospital, Sun Yat-sen University, Guangdong Provincial Key Laboratory for Diagnosis and Treatment of Major Neurological Diseases, Guangzhou 510080, China
