Anatomic resection for hepatoceilular carcinoma ≤ 5 cm: a Meta analysis
TIAN Yun-hong, LI Jing-dong, ZHAO Guo-gang, PENG Yong, SHI Gang, XU Wei, LI De-xin, LI Qiang
Published 2012-04-25
Cite as Chin J Gen Surg, 2012,27(04): 310-313. DOI: 10.3760/cma.j.issn.1007-631x.2012.04.016
Abstract
Objective To evaluate the impact of anatomic and non-anatomic liver resection on prognosis of patients with small hepatocellular carcinoma ( HCC ) using a Meta-analysis.Methods Literature on anatomic versus non-anatomic liver resection for the treatment of small HCC ( ≤5 cm) was retrieved. Results Four nonrandomized controlled trials were included consisting of 776 patients:484 undergoing anatomic liver resection and 292 non-anatomic resection.The age ranged from 53.4 to 63.0 years.Male ∶ female ratio was 3.56 ∶ 1.87.1% patients were Child-Pugh class A.Most patients (94.5% ) had a single tumor.No significant differences were found conceming the 1,3,and 5 year disease-free survival rate between the two groups.There was no significant difference in overall survival and disease-free survival between the two groups at 1,3,and 5 years.Sensitivity analysis found anatomic resection was superior to non-anatomic resection in 3 year disease free survival rate (OR =0.72,95% CI:0.52 - 0.99,P =0.04). Conclusions Anatomic liver resection elevated the 3 year disease free survival rate of patients with small hepatocellular carcinoma when compared with non-anatomic hepatectomy but failed to further elevate long-term disease free survival and overall survival.
Key words:
Carcinoma,hepatocellular; Hepatectomy; Prognosis; Meta-analysis
Contributor Information
TIAN Yun-hong
Department of General Surgery, the Affiliated Hospital of North Sichuan Medical College, Nanchong 637007, China
LI Jing-dong
Department of General Surgery, the Affiliated Hospital of North Sichuan Medical College, Nanchong 637007, China
ZHAO Guo-gang
Department of General Surgery, the Affiliated Hospital of North Sichuan Medical College, Nanchong 637007, China
PENG Yong
Department of General Surgery, the Affiliated Hospital of North Sichuan Medical College, Nanchong 637007, China
SHI Gang
Department of General Surgery, the Affiliated Hospital of North Sichuan Medical College, Nanchong 637007, China
XU Wei
Department of General Surgery, the Affiliated Hospital of North Sichuan Medical College, Nanchong 637007, China
LI De-xin
Department of General Surgery, the Affiliated Hospital of North Sichuan Medical College, Nanchong 637007, China
LI Qiang
Department of General Surgery, the Affiliated Hospital of North Sichuan Medical College, Nanchong 637007, China